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10.1002/jmv.25758 http://scihub22266oqcxt.onion/10.1002/jmv.25758 32167166!7228214!32167166     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=32167166&cmd=llinks): Failed to open stream: HTTP request failed! 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An exclusive 42 amino acid signature in pp1ab protein provides insights into the evolutive history of the 2019 novel human-pathogenic coronavirus (SARS-CoV-2) |pdf=|usr=}}{{32167166}} gab.com Text An exclusive 42 amino acid signature in pp1ab protein provides insights into the evolutive history of the 2019 novel human-pathogenic coronavirus (SARS-CoV-2) JO: J Med Virol http://www.kidney.de/pget.php?&tw=1&pmid=32167166 #FOAvip The city of Wuhan, Hubei province, China, was the origin of a severe pneumonia outbreak in December 2019, attributed to a novel coronavirus (severe acute respiratory syndrome coronavirus 2 [SARS-CoV-2]), causing a total of 2761 deaths and 81109 cases (25 February 2020). SARS-CoV-2 belongs to genus Betacoronavirus, subgenus Sarbecovirus. The polyprotein 1ab (pp1ab) remains unstudied thoroughly since it is similar to other sarbecoviruses. In this short communication, we performed phylogenetic-structural sequence analysis of pp1ab protein of SARS-CoV-2. The analysis showed that the viral pp1ab has not changed in most isolates throughout the outbreak time, but interestingly a deletion of 8 aa in the virulence factor nonstructural protein 1 was found in a virus isolated from a Japanese patient that did not display critical symptoms. While comparing pp1ab protein with other betacoronaviruses, we found a 42 amino acid signature that is only present in SARS-CoV-2 (AS-SCoV2). Members from clade 2 of sarbecoviruses have traces of this signature. The AS-SCoV2 located in the acidic-domain of papain-like protein of SARS-CoV-2 and bat-SL-CoV-RatG13 guided us to suggest that the novel 2019 coronavirus probably emerged by genetic drift from bat-SL-CoV-RaTG13. The implication of this amino acid signature in papain-like protein structure arrangement and function is something worth to be explored. Twit Text FOAVip An exclusive 42 amino acid signature in pp1ab protein provides insights into the evolutive history of the 2019 novel human-pathogenic coronavirus (SARS-CoV-2) ????J Med Virol http://www.kidney.de/pget.php?&tw=1&pmid=32167166 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32167166 #FOAvip English Wikipedia <ref>{{Cite pmid|32167166}}</ref> An exclusive 42 amino acid signature in pp1ab protein provides insights into the evolutive history of the 2019 novel human-pathogenic coronavirus (SARS-CoV-2) #MMPMID32167166 Cardenas-Conejo Y; Linan-Rico A; Garcia-Rodriguez DA; Centeno-Leija S; Serrano-Posada H J Med Virol 2020[Jun]; 92 (6): 688-692 PMID32167166show ga The city of Wuhan, Hubei province, China, was the origin of a severe pneumonia outbreak in December 2019, attributed to a novel coronavirus (severe acute respiratory syndrome coronavirus 2 [SARS-CoV-2]), causing a total of 2761 deaths and 81109 cases (25 February 2020). SARS-CoV-2 belongs to genus Betacoronavirus, subgenus Sarbecovirus. The polyprotein 1ab (pp1ab) remains unstudied thoroughly since it is similar to other sarbecoviruses. In this short communication, we performed phylogenetic-structural sequence analysis of pp1ab protein of SARS-CoV-2. The analysis showed that the viral pp1ab has not changed in most isolates throughout the outbreak time, but interestingly a deletion of 8 aa in the virulence factor nonstructural protein 1 was found in a virus isolated from a Japanese patient that did not display critical symptoms. While comparing pp1ab protein with other betacoronaviruses, we found a 42 amino acid signature that is only present in SARS-CoV-2 (AS-SCoV2). Members from clade 2 of sarbecoviruses have traces of this signature. The AS-SCoV2 located in the acidic-domain of papain-like protein of SARS-CoV-2 and bat-SL-CoV-RatG13 guided us to suggest that the novel 2019 coronavirus probably emerged by genetic drift from bat-SL-CoV-RaTG13. The implication of this amino acid signature in papain-like protein structure arrangement and function is something worth to be explored. |*Pandemics[MESH] |*Phylogeny[MESH] |Amino Acid Sequence[MESH] |Animals[MESH] |Base Sequence[MESH] |Betacoronavirus/classification/*genetics/isolation & purification/pathogenicity[MESH] |COVID-19[MESH] |Chiroptera/microbiology[MESH] |Computational Biology/methods[MESH] |Coronavirus Infections/*epidemiology/transmission/virology[MESH] |Coronavirus Papain-Like Proteases[MESH] |Evolution, Molecular[MESH] |Gene Expression[MESH] |Humans[MESH] |Papain/genetics[MESH] |Pneumonia, Viral/*epidemiology/transmission/virology[MESH] |Polyproteins[MESH] |SARS-CoV-2[MESH] |Sequence Alignment[MESH] |Sequence Homology, Amino Acid[MESH] |Severe acute respiratory syndrome-related coronavirus/classification/*genetics/pathogenicity[MESH] |Viral Nonstructural Proteins/genetics[MESH]An exclusive 42 amino acid signature in pp1ab protein provides insight(epmc).pdf DeepDyve Pubget Overpricing