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Enhanced isolation of SARS-CoV-2 by TMPRSS2-expressing cells #MMPMID32165541
Matsuyama S; Nao N; Shirato K; Kawase M; Saito S; Takayama I; Nagata N; Sekizuka T; Katoh H; Kato F; Sakata M; Tahara M; Kutsuna S; Ohmagari N; Kuroda M; Suzuki T; Kageyama T; Takeda M
Proc Natl Acad Sci U S A 2020[Mar]; 117 (13): 7001-7003 PMID32165541show ga
A novel betacoronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which caused a large respiratory outbreak in Wuhan, China in December 2019, is currently spreading across many countries globally. Here, we show that a TMPRSS2-expressing VeroE6 cell line is highly susceptible to SARS-CoV-2 infection, making it useful for isolating and propagating SARS-CoV-2. Our results reveal that, in common with SARS- and Middle East respiratory syndrome-CoV, SARS-CoV-2 infection is enhanced by TMPRSS2.