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Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 J+Am+Acad+Dermatol 2020 ; 83 (1): 123-130 Nephropedia Template TP
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The Alopecia Areata Consensus of Experts (ACE) study: Results of an international expert opinion on treatments for alopecia areata #MMPMID32165196
Meah N; Wall D; York K; Bhoyrul B; Bokhari L; Sigall DA; Bergfeld WF; Betz RC; Blume-Peytavi U; Callender V; Chitreddy V; Combalia A; Cotsarelis G; Craiglow B; Donovan J; Eisman S; Farrant P; Green J; Grimalt R; Harries M; Hordinsky M; Irvine AD; Itami S; Jolliffe V; King B; Lee WS; McMichael A; Messenger A; Mirmirani P; Olsen E; Orlow SJ; Piraccini BM; Rakowska A; Reygagne P; Roberts JL; Rudnicka L; Shapiro J; Sharma P; Tosti A; Vogt A; Wade M; Yip L; Zlotogorski A; Sinclair R
J Am Acad Dermatol 2020[Jul]; 83 (1): 123-130 PMID32165196show ga
BACKGROUND: A systematic review failed to identify any systemic therapy used in alopecia areata (AA) where use is supported by robust evidence from high-quality randomized controlled trials. OBJECTIVE: To produce an international consensus statement on the use and utility of various treatments for AA. METHODS: Fifty hair experts from 5 continents were invited to participate in a 3-round Delphi process. Agreement of 66% or greater was considered consensus. RESULTS: In the first round, consensus was achieved in 22 of 423 (5%) questions. After a face-to-face meeting in round 3, overall, consensus was achieved for only 130 (33%) treatment-specific questions. There was greater consensus for intralesional treatment of AA (19 [68%]) followed by topical treatment (25 [43%]). Consensus was achieved in 45 (36%) questions pertaining to systemic therapies in AA. The categories with the least consensus were phototherapy and nonprescription therapies. LIMITATIONS: The study included a comprehensive list of systemic treatments for AA but not all treatments used. CONCLUSION: Despite divergent opinions among experts, consensus was achieved on a number of pertinent questions. The concluding statement also highlights areas where expert consensus is lacking and where an international patient registry could enable further research.