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10.1016/j.antiviral.2020.104714 http://scihub22266oqcxt.onion/10.1016/j.antiviral.2020.104714 32165083!7111628!32165083     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=32165083&cmd=llinks): Failed to open stream: HTTP request failed! 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Inhibition of herpes simplex virus by myricetin through targeting viral gD protein and cellular EGFR/PI3K/Akt pathway |pdf=|usr=}}{{32165083}} gab.com Text Inhibition of herpes simplex virus by myricetin through targeting viral gD protein and cellular EGFR/PI3K/Akt pathway JO: Antiviral Res http://www.kidney.de/pget.php?&tw=1&pmid=32165083 #FOAvip Myricetin, a common dietary flavonoid, was reported to possess many different biological activities such as anti-oxidant, anti-inflammatory, and antiviral effects. In this study, we explored the anti-HSV effects and mechanisms of myricetin both in vitro and in vivo. The results showed that myricetin possessed anti-HSV-1 and HSV-2 activities with very low toxicity, superior to the effects of acyclovir. Myricetin may block HSV infection through direct interaction with virus gD protein to interfere with virus adsorption and membrane fusion, which was different from the nucleoside analogues such as acyclovir. Myricetin also down-regulate the cellular EGFR/PI3K/Akt signaling pathway to further inhibit HSV infection and its subsequent replication. Most importantly, intraperitoneal therapy of myricetin markedly improved mice survival and reduced virus titers in both lungs and spinal cord. Therefore, the natural dietary flavonoid myricetin has potential to be developed into a novel anti-HSV agent targeting both virus gD protein and cellular EGFR/PI3K/Akt pathway. Twit Text FOAVip Inhibition of herpes simplex virus by myricetin through targeting viral gD protein and cellular EGFR/PI3K/Akt pathway ????Antiviral Res http://www.kidney.de/pget.php?&tw=1&pmid=32165083 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32165083 #FOAvip English Wikipedia <ref>{{Cite pmid|32165083}}</ref> Inhibition of herpes simplex virus by myricetin through targeting viral gD protein and cellular EGFR/PI3K/Akt pathway #MMPMID32165083 Li W; Xu C; Hao C; Zhang Y; Wang Z; Wang S; Wang W Antiviral Res 2020[May]; 177 (ä): 104714 PMID32165083show ga Myricetin, a common dietary flavonoid, was reported to possess many different biological activities such as anti-oxidant, anti-inflammatory, and antiviral effects. In this study, we explored the anti-HSV effects and mechanisms of myricetin both in vitro and in vivo. The results showed that myricetin possessed anti-HSV-1 and HSV-2 activities with very low toxicity, superior to the effects of acyclovir. Myricetin may block HSV infection through direct interaction with virus gD protein to interfere with virus adsorption and membrane fusion, which was different from the nucleoside analogues such as acyclovir. Myricetin also down-regulate the cellular EGFR/PI3K/Akt signaling pathway to further inhibit HSV infection and its subsequent replication. Most importantly, intraperitoneal therapy of myricetin markedly improved mice survival and reduced virus titers in both lungs and spinal cord. Therefore, the natural dietary flavonoid myricetin has potential to be developed into a novel anti-HSV agent targeting both virus gD protein and cellular EGFR/PI3K/Akt pathway. |Animals[MESH] |Antiviral Agents/*pharmacology[MESH] |Chlorocebus aethiops[MESH] |Female[MESH] |Flavonoids/*pharmacology[MESH] |Genes, erbB-1[MESH] |Herpes Simplex/drug therapy[MESH] |Herpesvirus 1, Human/*drug effects[MESH] |Herpesvirus 2, Human/drug effects[MESH] |Mice[MESH] |Mice, Inbred BALB C[MESH] |Phosphatidylinositol 3-Kinases/metabolism[MESH] |Proto-Oncogene Proteins c-akt/metabolism[MESH] |Signal Transduction/*drug effects[MESH] |Vero Cells[MESH] |Viral Envelope Proteins/*antagonists & inhibitors/metabolism[MESH]Inhibition of herpes simplex virus by myricetin through targeting vira(epmc).pdf DeepDyve Pubget Overpricing