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10.1684/mrh.2019.0456 http://scihub22266oqcxt.onion/10.1684/mrh.2019.0456 32162606!ä!32162606 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Magnes+Res 2019 ; 32 (3): 54-62 Nephropedia Template TP {{tp|p=32162606|t=2019. Reactive oxygen species are implicated in altering magnesium homeostasis in endothelial cells exposed to high glucose |pdf=|usr=}}{{32162606}} gab.com Text Reactive oxygen species are implicated in altering magnesium homeostasis in endothelial cells exposed to high glucose JO: Magnes Res http://www.kidney.de/pget.php?&tw=1&pmid=32162606 #FOAvip Transient Receptor Potential Melastatin (TRPM)7 is important in maintaining the intracellular homeostasis of magnesium (Mg), which is instrumental for vital cellular functions. Since the upregulation of TRPM7 has been proposed as a marker of endothelial dysfunction, we evaluated the effects of high glucose, which markedly impacts endothelial performance, on TRPM7 and intracellular Mg homeostasis in human macrovascular endothelial cells. We show that glucose-induced free radicals increase the amounts of TRPM7 as well as total intracellular magnesium. On the contrary, the highly selective Mg transporter MagT1 is not modulated by high glucose, hydrogen peroxide and low extracellular magnesium. We conclude that in endothelial cells high glucose alters Mg homeostasis through the upregulation of TRPM7. Twit Text FOAVip Reactive oxygen species are implicated in altering magnesium homeostasis in endothelial cells exposed to high glucose ????Magnes Res http://www.kidney.de/pget.php?&tw=1&pmid=32162606 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32162606 #FOAvip English Wikipedia <ref>{{Cite pmid|32162606}}</ref> Reactive oxygen species are implicated in altering magnesium homeostasis in endothelial cells exposed to high glucose #MMPMID32162606 Scrimieri R; Locatelli L; Cazzola R; Maier JAM; Cazzaniga A Magnes Res 2019[Aug]; 32 (3): 54-62 PMID32162606show ga Transient Receptor Potential Melastatin (TRPM)7 is important in maintaining the intracellular homeostasis of magnesium (Mg), which is instrumental for vital cellular functions. Since the upregulation of TRPM7 has been proposed as a marker of endothelial dysfunction, we evaluated the effects of high glucose, which markedly impacts endothelial performance, on TRPM7 and intracellular Mg homeostasis in human macrovascular endothelial cells. We show that glucose-induced free radicals increase the amounts of TRPM7 as well as total intracellular magnesium. On the contrary, the highly selective Mg transporter MagT1 is not modulated by high glucose, hydrogen peroxide and low extracellular magnesium. We conclude that in endothelial cells high glucose alters Mg homeostasis through the upregulation of TRPM7. |Adenosine Triphosphate/analysis/metabolism[MESH] |Cells, Cultured[MESH] |Endothelial Cells/*drug effects/*metabolism[MESH] |Glucose/*pharmacology[MESH] |Homeostasis/*drug effects[MESH] |Human Umbilical Vein Endothelial Cells/*drug effects/metabolism[MESH] |Humans[MESH] |Magnesium/analysis/*metabolism[MESH]Reactive oxygen species are implicated in altering magnesium homeostas(epmc).pdf DeepDyve Pubget Overpricing