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10.1016/j.cell.2020.02.058 http://scihub22266oqcxt.onion/10.1016/j.cell.2020.02.058 32155444!7102599!32155444     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell 2020 ; 181 (2): 281-292.e6 Nephropedia Template TP {{tp|p=32155444|t=2020. Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein |pdf=|usr=}}{{32155444}} gab.com Text Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein JO: Cell http://www.kidney.de/pget.php?&tw=1&pmid=32155444 #FOAvip The emergence of SARS-CoV-2 has resulted in >90,000 infections and >3,000 deaths. Coronavirus spike (S) glycoproteins promote entry into cells and are the main target of antibodies. We show that SARS-CoV-2 S uses ACE2 to enter cells and that the receptor-binding domains of SARS-CoV-2 S and SARS-CoV S bind with similar affinities to human ACE2, correlating with the efficient spread of SARS-CoV-2 among humans. We found that the SARS-CoV-2 S glycoprotein harbors a furin cleavage site at the boundary between the S(1)/S(2) subunits, which is processed during biogenesis and sets this virus apart from SARS-CoV and SARS-related CoVs. We determined cryo-EM structures of the SARS-CoV-2 S ectodomain trimer, providing a blueprint for the design of vaccines and inhibitors of viral entry. Finally, we demonstrate that SARS-CoV S murine polyclonal antibodies potently inhibited SARS-CoV-2 S mediated entry into cells, indicating that cross-neutralizing antibodies targeting conserved S epitopes can be elicited upon vaccination. Twit Text FOAVip Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein ????Cell http://www.kidney.de/pget.php?&tw=1&pmid=32155444 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32155444 #FOAvip English Wikipedia <ref>{{Cite pmid|32155444}}</ref> Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein #MMPMID32155444 Walls AC; Park YJ; Tortorici MA; Wall A; McGuire AT; Veesler D Cell 2020[Apr]; 181 (2): 281-292.e6 PMID32155444show ga The emergence of SARS-CoV-2 has resulted in >90,000 infections and >3,000 deaths. Coronavirus spike (S) glycoproteins promote entry into cells and are the main target of antibodies. We show that SARS-CoV-2 S uses ACE2 to enter cells and that the receptor-binding domains of SARS-CoV-2 S and SARS-CoV S bind with similar affinities to human ACE2, correlating with the efficient spread of SARS-CoV-2 among humans. We found that the SARS-CoV-2 S glycoprotein harbors a furin cleavage site at the boundary between the S(1)/S(2) subunits, which is processed during biogenesis and sets this virus apart from SARS-CoV and SARS-related CoVs. We determined cryo-EM structures of the SARS-CoV-2 S ectodomain trimer, providing a blueprint for the design of vaccines and inhibitors of viral entry. Finally, we demonstrate that SARS-CoV S murine polyclonal antibodies potently inhibited SARS-CoV-2 S mediated entry into cells, indicating that cross-neutralizing antibodies targeting conserved S epitopes can be elicited upon vaccination. |Amino Acid Sequence[MESH] |Angiotensin-Converting Enzyme 2[MESH] |Antibodies, Neutralizing/metabolism/pharmacology[MESH] |Antigens, Viral/chemistry/immunology/metabolism[MESH] |Betacoronavirus/chemistry/*metabolism[MESH] |Cell Line[MESH] |Cryoelectron Microscopy[MESH] |Humans[MESH] |Models, Molecular[MESH] |Peptidyl-Dipeptidase A/metabolism[MESH] |Receptors, Virus/chemistry/metabolism[MESH] |SARS-CoV-2[MESH] |Severe acute respiratory syndrome-related coronavirus/metabolism[MESH] |Spike Glycoprotein, Coronavirus/*chemistry/immunology/metabolism/*ultrastructure[MESH]Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycopro(epmc).pdf DeepDyve Pubget Overpricing