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10.1053/j.ackd.2019.08.006 http://scihub22266oqcxt.onion/10.1053/j.ackd.2019.08.006 32147003!7080294!32147003     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Adv+Chronic+Kidney+Dis 2020 ; 27 (1): 56-66 Nephropedia Template TP {{tp|p=32147003|t=2020. The Many Faces of Calcineurin Inhibitor Toxicity-What the FK?|pdf=|usr=}}{{32147003}} gab.com Text The Many Faces of Calcineurin Inhibitor Toxicity-What the FK JO: Adv Chronic Kidney Dis http://www.kidney.de/pget.php?&tw=1&pmid=32147003 #FOAvip Calcineurin inhibitors (CNIs) are both the savior and Achilles' heel of kidney transplantation. Although CNIs have significantly reduced rates of acute rejection, their numerous toxicities can plague kidney transplant recipients. By 10 years, virtually all allografts will have evidence of CNI nephrotoxicity. CNIs have been strongly associated with hypertension, dyslipidemia, and new onset of diabetes after transplantation-significantly contributing to cardiovascular risk in the kidney transplant recipient. Multiple electrolyte derangements including hyperkalemia, hypomagnesemia, hypercalciuria, metabolic acidosis, and hyperuricemia may be challenging to manage for the clinician. Finally, CNI-associated tremor, gingival hyperplasia, and defects in hair growth can have a significant impact on the transplant recipient's quality of life. In this review, the authors briefly discuss the pharmacokinetics of CNI and discuss the numerous clinically relevant toxicities of commonly used CNIs, cyclosporine and tacrolimus. Twit Text FOAVip The Many Faces of Calcineurin Inhibitor Toxicity-What the FK ????Adv Chronic Kidney Dis http://www.kidney.de/pget.php?&tw=1&pmid=32147003 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32147003 #FOAvip English Wikipedia <ref>{{Cite pmid|32147003}}</ref> The Many Faces of Calcineurin Inhibitor Toxicity-What the FK? #MMPMID32147003 Farouk SS; Rein JL Adv Chronic Kidney Dis 2020[Jan]; 27 (1): 56-66 PMID32147003show ga Calcineurin inhibitors (CNIs) are both the savior and Achilles' heel of kidney transplantation. Although CNIs have significantly reduced rates of acute rejection, their numerous toxicities can plague kidney transplant recipients. By 10 years, virtually all allografts will have evidence of CNI nephrotoxicity. CNIs have been strongly associated with hypertension, dyslipidemia, and new onset of diabetes after transplantation-significantly contributing to cardiovascular risk in the kidney transplant recipient. Multiple electrolyte derangements including hyperkalemia, hypomagnesemia, hypercalciuria, metabolic acidosis, and hyperuricemia may be challenging to manage for the clinician. Finally, CNI-associated tremor, gingival hyperplasia, and defects in hair growth can have a significant impact on the transplant recipient's quality of life. In this review, the authors briefly discuss the pharmacokinetics of CNI and discuss the numerous clinically relevant toxicities of commonly used CNIs, cyclosporine and tacrolimus. |*Kidney Transplantation[MESH] |Calcineurin Inhibitors/*adverse effects/pharmacokinetics/therapeutic use[MESH] |Graft Rejection/prevention & control[MESH] |Humans[MESH]The Many Faces of Calcineurin Inhibitor Toxicity-What the FK?(epmc).pdf DeepDyve Pubget Overpricing