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10.1021/acscentsci.9b01149

http://scihub22266oqcxt.onion/10.1021/acscentsci.9b01149
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32123740!7047273!32123740
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suck abstract from ncbi


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pmid32123740      ACS+Cent+Sci 2020 ; 6 (2): 226-231
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  • Synthesis of Phospho-Amino Acid Analogues as Tissue Adhesive Cement Additives #MMPMID32123740
  • Spicer CD; Pujari-Palmer M; Autefage H; Insley G; Procter P; Engqvist H; Stevens MM
  • ACS Cent Sci 2020[Feb]; 6 (2): 226-231 PMID32123740show ga
  • In this paper we report the synthesis of a library of phospho-amino acid analogues, via a novel single-step allyl-phosphoester protection/Pd-mediated deprotection strategy. These phosphoserine and phosphotyrosine analogues were then applied as additives to create adhesive calcium phosphate cements, allowing us to probe the chemical origins of the increased surface binding strength. We demonstrate the importance of multiple calcium binding motifs in mediating adhesion, as well as highlighting the crucial role played by substrate hydrophobicity and orientation in controlling binding strength.
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