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10.3390/biom10030366

http://scihub22266oqcxt.onion/10.3390/biom10030366
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32120929!7175275!32120929
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suck abstract from ncbi


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pmid32120929      Biomolecules 2020 ; 10 (3): ä
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  • Antiviral Action of Tryptanthrin Isolated from Strobilanthes cusia Leaf against Human Coronavirus NL63 #MMPMID32120929
  • Tsai YC; Lee CL; Yen HR; Chang YS; Lin YP; Huang SH; Lin CW
  • Biomolecules 2020[Feb]; 10 (3): ä PMID32120929show ga
  • Strobilanthes cusia (Nees) Kuntze is a Chinese herbal medicine used in the treatment of respiratory virus infections. The methanol extract of S. cusia leaf contains chemical components such as beta-sitosterol, indirubin, tryptanthrin, betulin, indigodole A, and indigodole B that have diverse biological activities. However, the antiviral action of S. cusia leaf and its components against human coronavirus remains to be elucidated. Human coronavirus NL63 infection is frequent among immunocompromised individuals, young children, and in the elderly. This study investigated the anti-Human coronavirus NL63 (HCoV-NL63) activity of the methanol extract of S. cusia leaf and its major components. The methanol extract of S. cusia leaf effectively inhibited the cytopathic effect (CPE) and virus yield (IC(50) = 0.64 mug/mL) in HCoV-NL63-infected cells. Moreover, this extract potently inhibited the HCoV-NL63 infection in a concentration-dependent manner. Among the six components identified in the methanol extract of S. cusia leaf, tryptanthrin and indigodole B (5aR-ethyltryptanthrin) exhibited potent antiviral activity in reducing the CPE and progeny virus production. The IC(50) values against virus yield were 1.52 muM and 2.60 muM for tryptanthrin and indigodole B, respectively. Different modes of time-of-addition/removal assay indicated that tryptanthrin prevented the early and late stages of HCoV-NL63 replication, particularly by blocking viral RNA genome synthesis and papain-like protease 2 activity. Notably, tryptanthrin (IC(50) = 0.06 muM) and indigodole B (IC(50) = 2.09 muM) exhibited strong virucidal activity as well. This study identified tryptanthrin as the key active component of S. cusia leaf methanol extract that acted against HCoV-NL63 in a cell-type independent manner. The results specify that tryptanthrin possesses antiviral potential against HCoV-NL63 infection.
  • |Acanthaceae/*chemistry/metabolism[MESH]
  • |Animals[MESH]
  • |Antiviral Agents/chemistry/isolation & purification/*pharmacology/therapeutic use[MESH]
  • |Cell Line[MESH]
  • |Cell Survival/drug effects[MESH]
  • |Coronavirus Infections/drug therapy/virology[MESH]
  • |Coronavirus NL63, Human/isolation & purification/*physiology[MESH]
  • |Humans[MESH]
  • |Macaca mulatta[MESH]
  • |Medicine, Chinese Traditional[MESH]
  • |Plant Extracts/chemistry/pharmacology[MESH]
  • |Plant Leaves/chemistry/metabolism[MESH]
  • |Quinazolines/chemistry/isolation & purification/*pharmacology/therapeutic use[MESH]


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