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Neuroanatomy, Nucleus Gustatory #MMPMID32119409
Obiefuna S; Donohoe C
StatPearls-/-ä 2025[Jan]; ä (ä): ä PMID32119409show ga
The act of perceiving taste is called gustation. The ability to taste is strongly linked to our ability to smell and olfaction. Taste and smell dysfunction are generally low on the list of key clinical symptoms. However, the recent coronavirus disease 2019 (COVID-19) caused by the specific virus (SARS-COV-2) pandemic has been associated with loss of sense of smell and taste in up to 75% of patients both as the presenting or only symptom in patients with mild disease or as the initial symptom in patients who may ultimately progress to more serious respiratory failure due to pneumonia. The diagnostic utility of anosmia exhibits low sensitivity (23-43%) but high specificity (93-99%) for the diagnosis of SARS-COV-2) infection. Similar symptoms were reported during the SARS (severe acute respiratory syndrome)-COV outbreak 2003. Changes in taste and smell are also common in viral illnesses like the common cold or flu. As taste and smell are closely intertwined, it is believed that the vast majority of cases where taste is lost are rooted in damage to the olfactory system (smell). The gustatory system (taste) is usually not selectively impacted by viral upper respiratory infections. Entry of SARS-COV-2 into the olfactory epithelial is related to the neurotropic and neuroinvasive properties of the virus, which were previously reported in the previous SARS outbreak. SARS-COV-2 can enter non-neuronal cells of the olfactory epithelium and olfactory bulb, including supporting sustentacular cells and pericytes, which express angiotensin-converting enzyme-2. The viral spike protein binds to the angiotensin-converting enzyme-2 receptor expressed and these supporting elements, which are essential for the integrity and function of the olfactory sensory neurons, ultimately resulting in anosmia. Approximately 10% of patients show long-lasting impairment of smell and taste. The brain has a dedicated area chiefly responsible for perceiving and distinguishing different tastes called the gustatory cortex. The terminal connection serving taste perception is located in the anterior insula in the temporal lobe and frontal opercular region. The system differentiates the subtleties of salty, sweet, sour, bitter, and umami (Japanese for savory, monosodium glutamate), the essence of flavor in our food. First-order neurons originate as peripheral taste chemoreceptors found in papillae on the tongue's upper surface, soft palate, pharynx, and upper aspect of the esophagus. Chemoreceptor stimulation, specific for individual tastes, triggers cellular depolarization, ultimately synapsing topographically with primary sensory axons that run in the chorda tympani and greater superior petrosal branches of the facial nerve CN VII (dorsal surface of tongue), the lingual branch of the glossopharyngeal nerve CN IX (soft palate and pharynx) and the vagus nerve CN X(upper part of the esophagus). The central axon of these primary sensory neurons projects from their specific cranial nerve ganglia to the solitary tract in the medulla. Axons from the rostral gustatory solitary nucleus project to the ventral posterior medial nucleus of the thalamus VPM and ultimately terminate, both crossed and uncrossed, at the neocortex, the gustatory cortex (the anterior insula of the temporal lobe and frontal opercular region). Consciousness perception of flavor and experiencing the pleasurable (hedonic) value of food is subserved by the posterior part of the orbital frontal cortex. This area lies near the primary olfactory piriform cortex (smell), anatomically and physiologically, positioning olfaction with gustation. The gustatory nucleus is a group of neuron cell bodies that serve as an intermediate to relay gustation from the chemoreceptors in the mouth to the gustatory cortex. These neuron cell bodies are in the posterolateral portion of the brainstem, known as the nucleus of the solitary tract. Specifically, the neurons found here are the second-order neurons in the pathway for gestation (see Image. Gustatory Pathway). The gustatory nucleus receives its input from first-order neurons: the afferent cranial nerve fibers from the facial (VII), glossopharyngeal (IX), and vagus (X) nerves. These fibers carry gustation from the anterior two-thirds of the tongue, posterior one-third of the tongue, and the epiglottis, respectively. JL Clarke and B Stilling first described the gustatory nuclei in the mid-19th century. Their early discoveries and contributions paved the way for what is known about the gustatory nucleus today. Due to its complexity, dysfunctions of taste can have clinical significance in fields including but not limited to neurosurgery, neurology, and otolaryngology. Therefore, knowledge of the function and structure of this neuroanatomical finding is essential in several medical practices.
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