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10.1002/jmv.25731 http://scihub22266oqcxt.onion/10.1002/jmv.25731 32104911!7228310!32104911     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Med+Virol 2020 ; 92 (6): 602-611 Nephropedia Template TP {{tp|p=32104911|t=2020. Evolutionary history, potential intermediate animal host, and cross-species analyses of SARS-CoV-2 |pdf=|usr=}}{{32104911}} gab.com Text Evolutionary history, potential intermediate animal host, and cross-species analyses of SARS-CoV-2 JO: J Med Virol http://www.kidney.de/pget.php?&tw=1&pmid=32104911 #FOAvip To investigate the evolutionary history of the recent outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in China, a total of 70 genomes of virus strains from China and elsewhere with sampling dates between 24 December 2019 and 3 February 2020 were analyzed. To explore the potential intermediate animal host of the SARS-CoV-2 virus, we reanalyzed virome data sets from pangolins and representative SARS-related coronaviruses isolates from bats, with particular attention paid to the spike glycoprotein gene. We performed phylogenetic, split network, transmission network, likelihood-mapping, and comparative analyses of the genomes. Based on Bayesian time-scaled phylogenetic analysis using the tip-dating method, we estimated the time to the most recent common ancestor and evolutionary rate of SARS-CoV-2, which ranged from 22 to 24 November 2019 and 1.19 to 1.31 x 10(-3) substitutions per site per year, respectively. Our results also revealed that the BetaCoV/bat/Yunnan/RaTG13/2013 virus was more similar to the SARS-CoV-2 virus than the coronavirus obtained from the two pangolin samples (SRR10168377 and SRR10168378). We also identified a unique peptide (PRRA) insertion in the human SARS-CoV-2 virus, which may be involved in the proteolytic cleavage of the spike protein by cellular proteases, and thus could impact host range and transmissibility. Interestingly, the coronavirus carried by pangolins did not have the RRAR motif. Therefore, we concluded that the human SARS-CoV-2 virus, which is responsible for the recent outbreak of COVID-19, did not come directly from pangolins. Twit Text FOAVip Evolutionary history, potential intermediate animal host, and cross-species analyses of SARS-CoV-2 ????J Med Virol http://www.kidney.de/pget.php?&tw=1&pmid=32104911 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32104911 #FOAvip English Wikipedia <ref>{{Cite pmid|32104911}}</ref> Evolutionary history, potential intermediate animal host, and cross-species analyses of SARS-CoV-2 #MMPMID32104911 Li X; Zai J; Zhao Q; Nie Q; Li Y; Foley BT; Chaillon A J Med Virol 2020[Jun]; 92 (6): 602-611 PMID32104911show ga To investigate the evolutionary history of the recent outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in China, a total of 70 genomes of virus strains from China and elsewhere with sampling dates between 24 December 2019 and 3 February 2020 were analyzed. To explore the potential intermediate animal host of the SARS-CoV-2 virus, we reanalyzed virome data sets from pangolins and representative SARS-related coronaviruses isolates from bats, with particular attention paid to the spike glycoprotein gene. We performed phylogenetic, split network, transmission network, likelihood-mapping, and comparative analyses of the genomes. Based on Bayesian time-scaled phylogenetic analysis using the tip-dating method, we estimated the time to the most recent common ancestor and evolutionary rate of SARS-CoV-2, which ranged from 22 to 24 November 2019 and 1.19 to 1.31 x 10(-3) substitutions per site per year, respectively. Our results also revealed that the BetaCoV/bat/Yunnan/RaTG13/2013 virus was more similar to the SARS-CoV-2 virus than the coronavirus obtained from the two pangolin samples (SRR10168377 and SRR10168378). We also identified a unique peptide (PRRA) insertion in the human SARS-CoV-2 virus, which may be involved in the proteolytic cleavage of the spike protein by cellular proteases, and thus could impact host range and transmissibility. Interestingly, the coronavirus carried by pangolins did not have the RRAR motif. Therefore, we concluded that the human SARS-CoV-2 virus, which is responsible for the recent outbreak of COVID-19, did not come directly from pangolins. |*Genome, Viral[MESH] |*Pandemics[MESH] |Amino Acid Sequence[MESH] |Animals[MESH] |Betacoronavirus/classification/*genetics/pathogenicity[MESH] |COVID-19[MESH] |Chiroptera/virology[MESH] |Coronavirus Infections/*epidemiology/*transmission/virology[MESH] |Eutheria/virology[MESH] |Evolution, Molecular[MESH] |Host Specificity[MESH] |Humans[MESH] |Phylogeny[MESH] |Pneumonia, Viral/*epidemiology/*transmission/virology[MESH] |SARS-CoV-2[MESH] |Sequence Alignment[MESH] |Sequence Homology, Amino Acid[MESH]Evolutionary history, potential intermediate animal host, and cross-sp(epmc).pdf DeepDyve Pubget Overpricing