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10.1038/s41564-020-0688-y http://scihub22266oqcxt.onion/10.1038/s41564-020-0688-y 32094589!7095430!32094589     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Microbiol 2020 ; 5 (4): 562-569 Nephropedia Template TP {{tp|p=32094589|t=2020. Functional assessment of cell entry and receptor usage for SARS-CoV-2 and other lineage B betacoronaviruses |pdf=|usr=}}{{32094589}} gab.com Text Functional assessment of cell entry and receptor usage for SARS-CoV-2 and other lineage B betacoronaviruses JO: Nat Microbiol http://www.kidney.de/pget.php?&tw=1&pmid=32094589 #FOAvip Over the past 20 years, several coronaviruses have crossed the species barrier into humans, causing outbreaks of severe, and often fatal, respiratory illness. Since SARS-CoV was first identified in animal markets, global viromics projects have discovered thousands of coronavirus sequences in diverse animals and geographic regions. Unfortunately, there are few tools available to functionally test these viruses for their ability to infect humans, which has severely hampered efforts to predict the next zoonotic viral outbreak. Here, we developed an approach to rapidly screen lineage B betacoronaviruses, such as SARS-CoV and the recent SARS-CoV-2, for receptor usage and their ability to infect cell types from different species. We show that host protease processing during viral entry is a significant barrier for several lineage B viruses and that bypassing this barrier allows several lineage B viruses to enter human cells through an unknown receptor. We also demonstrate how different lineage B viruses can recombine to gain entry into human cells, and confirm that human ACE2 is the receptor for the recently emerging SARS-CoV-2. Twit Text FOAVip Functional assessment of cell entry and receptor usage for SARS-CoV-2 and other lineage B betacoronaviruses ????Nat Microbiol http://www.kidney.de/pget.php?&tw=1&pmid=32094589 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32094589 #FOAvip English Wikipedia <ref>{{Cite pmid|32094589}}</ref> Functional assessment of cell entry and receptor usage for SARS-CoV-2 and other lineage B betacoronaviruses #MMPMID32094589 Letko M; Marzi A; Munster V Nat Microbiol 2020[Apr]; 5 (4): 562-569 PMID32094589show ga Over the past 20 years, several coronaviruses have crossed the species barrier into humans, causing outbreaks of severe, and often fatal, respiratory illness. Since SARS-CoV was first identified in animal markets, global viromics projects have discovered thousands of coronavirus sequences in diverse animals and geographic regions. Unfortunately, there are few tools available to functionally test these viruses for their ability to infect humans, which has severely hampered efforts to predict the next zoonotic viral outbreak. Here, we developed an approach to rapidly screen lineage B betacoronaviruses, such as SARS-CoV and the recent SARS-CoV-2, for receptor usage and their ability to infect cell types from different species. We show that host protease processing during viral entry is a significant barrier for several lineage B viruses and that bypassing this barrier allows several lineage B viruses to enter human cells through an unknown receptor. We also demonstrate how different lineage B viruses can recombine to gain entry into human cells, and confirm that human ACE2 is the receptor for the recently emerging SARS-CoV-2. |*Virus Internalization[MESH] |Angiotensin-Converting Enzyme 2[MESH] |Animals[MESH] |Betacoronavirus/chemistry/classification/*physiology[MESH] |CD13 Antigens/metabolism[MESH] |COVID-19[MESH] |Cell Line[MESH] |Coronavirus Infections/metabolism/virology[MESH] |Dipeptidyl Peptidase 4/metabolism[MESH] |Humans[MESH] |Mutation[MESH] |Pandemics[MESH] |Peptidyl-Dipeptidase A/chemistry/genetics/*metabolism[MESH] |Pneumonia, Viral/metabolism/virology[MESH] |Protein Domains[MESH] |Receptors, Coronavirus[MESH] |Receptors, Virus/chemistry/genetics/*metabolism[MESH] |Recombinant Fusion Proteins/metabolism[MESH] |SARS-CoV-2[MESH] |Severe acute respiratory syndrome-related coronavirus/chemistry/physiology[MESH] |Spike Glycoprotein, Coronavirus/chemistry/genetics/*metabolism[MESH]Functional assessment of cell entry and receptor usage for SARS-CoV-2 (epmc).pdf DeepDyve Pubget Overpricing