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10.1038/s41368-020-0074-x http://scihub22266oqcxt.onion/10.1038/s41368-020-0074-x 32094336!7039956!32094336     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Int+J+Oral+Sci 2020 ; 12 (1): 8 Nephropedia Template TP {{tp|p=32094336|t=2020. High expression of ACE2 receptor of 2019-nCoV on the epithelial cells of oral mucosa |pdf=|usr=}}{{32094336}} gab.com Text High expression of ACE2 receptor of 2019-nCoV on the epithelial cells of oral mucosa JO: Int J Oral Sci http://www.kidney.de/pget.php?&tw=1&pmid=32094336 #FOAvip It has been reported that ACE2 is the main host cell receptor of 2019-nCoV and plays a crucial role in the entry of virus into the cell to cause the final infection. To investigate the potential route of 2019-nCov infection on the mucosa of oral cavity, bulk RNA-seq profiles from two public databases including The Cancer Genome Atlas (TCGA) and Functional Annotation of The Mammalian Genome Cap Analysis of Gene Expression (FANTOM5 CAGE) dataset were collected. RNA-seq profiling data of 13 organ types with para-carcinoma normal tissues from TCGA and 14 organ types with normal tissues from FANTOM5 CAGE were analyzed in order to explore and validate the expression of ACE2 on the mucosa of oral cavity. Further, single-cell transcriptomes from an independent data generated in-house were used to identify and confirm the ACE2-expressing cell composition and proportion in oral cavity. The results demonstrated that the ACE2 expressed on the mucosa of oral cavity. Interestingly, this receptor was highly enriched in epithelial cells of tongue. Preliminarily, those findings have explained the basic mechanism that the oral cavity is a potentially high risk for 2019-nCoV infectious susceptibility and provided a piece of evidence for the future prevention strategy in dental clinical practice as well as daily life. Twit Text FOAVip High expression of ACE2 receptor of 2019-nCoV on the epithelial cells of oral mucosa ????Int J Oral Sci http://www.kidney.de/pget.php?&tw=1&pmid=32094336 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32094336 #FOAvip English Wikipedia <ref>{{Cite pmid|32094336}}</ref> High expression of ACE2 receptor of 2019-nCoV on the epithelial cells of oral mucosa #MMPMID32094336 Xu H; Zhong L; Deng J; Peng J; Dan H; Zeng X; Li T; Chen Q Int J Oral Sci 2020[Feb]; 12 (1): 8 PMID32094336show ga It has been reported that ACE2 is the main host cell receptor of 2019-nCoV and plays a crucial role in the entry of virus into the cell to cause the final infection. To investigate the potential route of 2019-nCov infection on the mucosa of oral cavity, bulk RNA-seq profiles from two public databases including The Cancer Genome Atlas (TCGA) and Functional Annotation of The Mammalian Genome Cap Analysis of Gene Expression (FANTOM5 CAGE) dataset were collected. RNA-seq profiling data of 13 organ types with para-carcinoma normal tissues from TCGA and 14 organ types with normal tissues from FANTOM5 CAGE were analyzed in order to explore and validate the expression of ACE2 on the mucosa of oral cavity. Further, single-cell transcriptomes from an independent data generated in-house were used to identify and confirm the ACE2-expressing cell composition and proportion in oral cavity. The results demonstrated that the ACE2 expressed on the mucosa of oral cavity. Interestingly, this receptor was highly enriched in epithelial cells of tongue. Preliminarily, those findings have explained the basic mechanism that the oral cavity is a potentially high risk for 2019-nCoV infectious susceptibility and provided a piece of evidence for the future prevention strategy in dental clinical practice as well as daily life. |*Betacoronavirus/pathogenicity[MESH] |*Mouth Mucosa/enzymology/virology[MESH] |*Tongue/metabolism/virology[MESH] |Angiotensin-Converting Enzyme 2[MESH] |COVID-19[MESH] |Coronavirus Infections/genetics/*transmission[MESH] |Databases, Genetic[MESH] |Epithelial Cells/metabolism/virology[MESH] |Gene Expression Profiling[MESH] |Humans[MESH] |Peptidyl-Dipeptidase A/*metabolism[MESH] |Pneumonia, Viral/genetics/*transmission[MESH]High expression of ACE2 receptor of 2019-nCoV on the epithelial cells (epmc).pdf DeepDyve Pubget Overpricing