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10.1016/j.ijid.2020.02.018

http://scihub22266oqcxt.onion/10.1016/j.ijid.2020.02.018
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32081774!7128205!32081774
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suck abstract from ncbi


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pmid32081774      Int+J+Infect+Dis 2020 ; 93 (ä): 268-276
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  • Discovery and development of safe-in-man broad-spectrum antiviral agents #MMPMID32081774
  • Andersen PI; Ianevski A; Lysvand H; Vitkauskiene A; Oksenych V; Bjoras M; Telling K; Lutsar I; Dumpis U; Irie Y; Tenson T; Kantele A; Kainov DE
  • Int J Infect Dis 2020[Apr]; 93 (ä): 268-276 PMID32081774show ga
  • Viral diseases are one of the leading causes of morbidity and mortality in the world. Virus-specific vaccines and antiviral drugs are the most powerful tools to combat viral diseases. However, broad-spectrum antiviral agents (BSAAs, i.e. compounds targeting viruses belonging to two or more viral families) could provide additional protection of the general population from emerging and re-emerging viral diseases, reinforcing the arsenal of available antiviral options. Here, we review discovery and development of BSAAs and summarize the information on 120 safe-in-man agents in a freely accessible database (https://drugvirus.info/). Future and ongoing pre-clinical and clinical studies will increase the number of BSAAs, expand the spectrum of their indications, and identify drug combinations for treatment of emerging and re-emerging viral infections as well as co-infections.
  • |*Antiviral Agents/therapeutic use[MESH]
  • |*Drug Development[MESH]
  • |*Drug Discovery[MESH]
  • |Animals[MESH]
  • |Humans[MESH]


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