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10.1016/j.ijid.2020.02.018 http://scihub22266oqcxt.onion/10.1016/j.ijid.2020.02.018 32081774!7128205!32081774     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=32081774&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       Int+J+Infect+Dis 2020 ; 93 (?): 268-276 Nephropedia Template TP {{tp|p=32081774|t=2020. Discovery and development of safe-in-man broad-spectrum antiviral agents |pdf=|usr=}}{{32081774}} gab.com Text Discovery and development of safe-in-man broad-spectrum antiviral agents JO: Int J Infect Dis http://www.kidney.de/pget.php?&tw=1&pmid=32081774 #FOAvip Viral diseases are one of the leading causes of morbidity and mortality in the world. Virus-specific vaccines and antiviral drugs are the most powerful tools to combat viral diseases. However, broad-spectrum antiviral agents (BSAAs, i.e. compounds targeting viruses belonging to two or more viral families) could provide additional protection of the general population from emerging and re-emerging viral diseases, reinforcing the arsenal of available antiviral options. Here, we review discovery and development of BSAAs and summarize the information on 120 safe-in-man agents in a freely accessible database (https://drugvirus.info/). Future and ongoing pre-clinical and clinical studies will increase the number of BSAAs, expand the spectrum of their indications, and identify drug combinations for treatment of emerging and re-emerging viral infections as well as co-infections. Twit Text FOAVip Discovery and development of safe-in-man broad-spectrum antiviral agents ????Int J Infect Dis http://www.kidney.de/pget.php?&tw=1&pmid=32081774 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32081774 #FOAvip English Wikipedia <ref>{{Cite pmid|32081774}}</ref> Discovery and development of safe-in-man broad-spectrum antiviral agents #MMPMID32081774 Andersen PI; Ianevski A; Lysvand H; Vitkauskiene A; Oksenych V; Bjoras M; Telling K; Lutsar I; Dumpis U; Irie Y; Tenson T; Kantele A; Kainov DE Int J Infect Dis 2020[Apr]; 93 (?): 268-276 PMID32081774show ga Viral diseases are one of the leading causes of morbidity and mortality in the world. Virus-specific vaccines and antiviral drugs are the most powerful tools to combat viral diseases. However, broad-spectrum antiviral agents (BSAAs, i.e. compounds targeting viruses belonging to two or more viral families) could provide additional protection of the general population from emerging and re-emerging viral diseases, reinforcing the arsenal of available antiviral options. Here, we review discovery and development of BSAAs and summarize the information on 120 safe-in-man agents in a freely accessible database (https://drugvirus.info/). Future and ongoing pre-clinical and clinical studies will increase the number of BSAAs, expand the spectrum of their indications, and identify drug combinations for treatment of emerging and re-emerging viral infections as well as co-infections. |*Antiviral Agents/therapeutic use[MESH] |*Drug Development[MESH] |*Drug Discovery[MESH] |Animals[MESH] |Humans[MESH]Discovery and development of safe-in-man broad-spectrum antiviral agen(epmc).pdf DeepDyve Pubget Overpricing