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10.1111/all.14238

http://scihub22266oqcxt.onion/10.1111/all.14238
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32077115!ä!32077115

suck abstract from ncbi


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pmid32077115      Allergy 2020 ; 75 (7): 1730-1741
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  • Clinical characteristics of 140 patients infected with SARS-CoV-2 in Wuhan, China #MMPMID32077115
  • Zhang JJ; Dong X; Cao YY; Yuan YD; Yang YB; Yan YQ; Akdis CA; Gao YD
  • Allergy 2020[Jul]; 75 (7): 1730-1741 PMID32077115show ga
  • BACKGROUND: Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has been widely spread. We aim to investigate the clinical characteristic and allergy status of patients infected with SARS-CoV-2. METHODS: Electronic medical records including demographics, clinical manifestation, comorbidities, laboratory data, and radiological materials of 140 hospitalized COVID-19 patients, with confirmed result of SARS-CoV-2 viral infection, were extracted and analyzed. RESULTS: An approximately 1:1 ratio of male (50.7%) and female COVID-19 patients was found, with an overall median age of 57.0 years. All patients were community-acquired cases. Fever (91.7%), cough (75.0%), fatigue (75.0%), and gastrointestinal symptoms (39.6%) were the most common clinical manifestations, whereas hypertension (30.0%) and diabetes mellitus (12.1%) were the most common comorbidities. Drug hypersensitivity (11.4%) and urticaria (1.4%) were self-reported by several patients. Asthma or other allergic diseases were not reported by any of the patients. Chronic obstructive pulmonary disease (COPD, 1.4%) patients and current smokers (1.4%) were rare. Bilateral ground-glass or patchy opacity (89.6%) was the most common sign of radiological finding. Lymphopenia (75.4%) and eosinopenia (52.9%) were observed in most patients. Blood eosinophil counts correlate positively with lymphocyte counts in severe (r = .486, P < .001) and nonsevere (r = .469, P < .001) patients after hospital admission. Significantly higher levels of D-dimer, C-reactive protein, and procalcitonin were associated with severe patients compared to nonsevere patients (all P < .001). CONCLUSION: Detailed clinical investigation of 140 hospitalized COVID-19 cases suggests eosinopenia together with lymphopenia may be a potential indicator for diagnosis. Allergic diseases, asthma, and COPD are not risk factors for SARS-CoV-2 infection. Older age, high number of comorbidities, and more prominent laboratory abnormalities were associated with severe patients.
  • |Adult[MESH]
  • |Aged[MESH]
  • |Aged, 80 and over[MESH]
  • |Betacoronavirus/*genetics[MESH]
  • |C-Reactive Protein/analysis[MESH]
  • |COVID-19[MESH]
  • |China/epidemiology[MESH]
  • |Community-Acquired Infections[MESH]
  • |Comorbidity[MESH]
  • |Coronavirus Infections/blood/*epidemiology/*physiopathology/virology[MESH]
  • |Diabetes Mellitus/*epidemiology[MESH]
  • |Eosinophils[MESH]
  • |Female[MESH]
  • |Hospitalization[MESH]
  • |Humans[MESH]
  • |Hypertension/*epidemiology[MESH]
  • |Lymphopenia[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/blood/*epidemiology/*physiopathology/virology[MESH]
  • |Risk Factors[MESH]
  • |SARS-CoV-2[MESH]


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