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  • Abnormal coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia #MMPMID32073213
  • Tang N; Li D; Wang X; Sun Z
  • J Thromb Haemost 2020[Apr]; 18 (4): 844-847 PMID32073213show ga
  • BACKGROUND: In the recent outbreak of novel coronavirus infection in Wuhan, China, significantly abnormal coagulation parameters in severe novel coronavirus pneumonia (NCP) cases were a concern. OBJECTIVES: To describe the coagulation feature of patients with NCP. METHODS: Conventional coagulation results and outcomes of 183 consecutive patients with confirmed NCP in Tongji hospital were retrospectively analyzed. RESULTS: The overall mortality was 11.5%, the non-survivors revealed significantly higher D-dimer and fibrin degradation product (FDP) levels, longer prothrombin time and activated partial thromboplastin time compared to survivors on admission (P < .05); 71.4% of non-survivors and 0.6% survivors met the criteria of disseminated intravascular coagulation during their hospital stay. CONCLUSIONS: The present study shows that abnormal coagulation results, especially markedly elevated D-dimer and FDP are common in deaths with NCP.
  • |*Betacoronavirus[MESH]
  • |*Blood Coagulation[MESH]
  • |Adolescent[MESH]
  • |Adult[MESH]
  • |Aged[MESH]
  • |Aged, 80 and over[MESH]
  • |China[MESH]
  • |Coronavirus Infections/*mortality/*physiopathology[MESH]
  • |Disseminated Intravascular Coagulation/*mortality/*virology[MESH]
  • |Female[MESH]
  • |Fibrin Fibrinogen Degradation Products/analysis[MESH]
  • |Humans[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Pandemics[MESH]
  • |Partial Thromboplastin Time[MESH]
  • |Pneumonia, Viral/*mortality/*physiopathology[MESH]
  • |Prothrombin Time[MESH]
  • |Retrospective Studies[MESH]
  • |Young Adult[MESH]

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  • suck abstract from ncbi

    844 4.18 2020