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10.1016/j.pharmthera.2020.107503 http://scihub22266oqcxt.onion/10.1016/j.pharmthera.2020.107503 32061923!7102585!32061923     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=32061923&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Pharmacol+Ther 2020 ; 209 (ä): 107503 Nephropedia Template TP {{tp|p=32061923|t=2020. Dipeptidyl peptidase 4 inhibitors and their potential immune modulatory functions |pdf=|usr=}}{{32061923}} gab.com Text Dipeptidyl peptidase 4 inhibitors and their potential immune modulatory functions JO: Pharmacol Ther http://www.kidney.de/pget.php?&tw=1&pmid=32061923 #FOAvip Dipeptidyl peptidase 4 (DPP4) inhibitors (DPP4is) are oral anti-diabetic drugs (OADs) for the treatment of type 2 diabetes mellitus (T2DM) through inhibiting the degradation of incretin peptides. Numerous investigations have been focused on the effects of DPP4is on glucose homeostasis. However, there are limited evidences demonstrating their Potential modulatory functions in the immune system. DPP4, originally known as the lymphocyte cell surface protein CD26, is widely expressed in many types of immune cells including CD4(+) and CD8(+) T cells, B cells, NK cells, dendritic cells, and macrophages; and regulate the functions of these cells. In addition, DPP4 is capable of modulating plenty of cytokines, chemokines and peptide hormones. Accordingly, DPP4/CD26 is speculated to be involved in various immune/inflammatory diseases and DPP4is may become a new drug class applied in these diseases. This review focuses on the regulatory effects of DPP4is on immune functions and their possible underlying mechanisms. Further clinical studies will be necessitated to fully evaluate the administration of DPP4is in diabetic patients with or without immune diseases. Twit Text FOAVip Dipeptidyl peptidase 4 inhibitors and their potential immune modulatory functions ????Pharmacol Ther http://www.kidney.de/pget.php?&tw=1&pmid=32061923 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32061923 #FOAvip English Wikipedia <ref>{{Cite pmid|32061923}}</ref> Dipeptidyl peptidase 4 inhibitors and their potential immune modulatory functions #MMPMID32061923 Shao S; Xu Q; Yu X; Pan R; Chen Y Pharmacol Ther 2020[May]; 209 (ä): 107503 PMID32061923show ga Dipeptidyl peptidase 4 (DPP4) inhibitors (DPP4is) are oral anti-diabetic drugs (OADs) for the treatment of type 2 diabetes mellitus (T2DM) through inhibiting the degradation of incretin peptides. Numerous investigations have been focused on the effects of DPP4is on glucose homeostasis. However, there are limited evidences demonstrating their Potential modulatory functions in the immune system. DPP4, originally known as the lymphocyte cell surface protein CD26, is widely expressed in many types of immune cells including CD4(+) and CD8(+) T cells, B cells, NK cells, dendritic cells, and macrophages; and regulate the functions of these cells. In addition, DPP4 is capable of modulating plenty of cytokines, chemokines and peptide hormones. Accordingly, DPP4/CD26 is speculated to be involved in various immune/inflammatory diseases and DPP4is may become a new drug class applied in these diseases. This review focuses on the regulatory effects of DPP4is on immune functions and their possible underlying mechanisms. Further clinical studies will be necessitated to fully evaluate the administration of DPP4is in diabetic patients with or without immune diseases. |Animals[MESH] |Diabetes Mellitus, Type 2/drug therapy/*immunology[MESH] |Dipeptidyl Peptidase 4/*immunology[MESH] |Dipeptidyl-Peptidase IV Inhibitors/*administration & dosage/immunology[MESH] |Humans[MESH] |Immunologic Factors/administration & dosage/*immunology[MESH] |Immunotherapy/methods/*trends[MESH]Dipeptidyl peptidase 4 inhibitors and their potential immune modulator(epmc).pdf DeepDyve Pubget Overpricing