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10.1002/jmv.25698 http://scihub22266oqcxt.onion/10.1002/jmv.25698 32022276!7166505!32022276     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Med+Virol 2020 ; 92 (5): 495-500 Nephropedia Template TP {{tp|p=32022276|t=2020. Immunoinformatics-aided identification of T cell and B cell epitopes in the surface glycoprotein of 2019-nCoV |pdf=|usr=}}{{32022276}} gab.com Text Immunoinformatics-aided identification of T cell and B cell epitopes in the surface glycoprotein of 2019-nCoV JO: J Med Virol http://www.kidney.de/pget.php?&tw=1&pmid=32022276 #FOAvip The 2019 novel coronavirus (2019-nCoV) outbreak has caused a large number of deaths with thousands of confirmed cases worldwide, especially in East Asia. This study took an immunoinformatics approach to identify significant cytotoxic T lymphocyte (CTL) and B cell epitopes in the 2019-nCoV surface glycoprotein. Also, interactions between identified CTL epitopes and their corresponding major histocompatibility complex (MHC) class I supertype representatives prevalent in China were studied by molecular dynamics simulations. We identified five CTL epitopes, three sequential B cell epitopes and five discontinuous B cell epitopes in the viral surface glycoprotein. Also, during simulations, the CTL epitopes were observed to be binding MHC class I peptide-binding grooves via multiple contacts, with continuous hydrogen bonds and salt bridge anchors, indicating their potential in generating immune responses. Some of these identified epitopes can be potential candidates for the development of 2019-nCoV vaccines. Twit Text FOAVip Immunoinformatics-aided identification of T cell and B cell epitopes in the surface glycoprotein of 2019-nCoV ????J Med Virol http://www.kidney.de/pget.php?&tw=1&pmid=32022276 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32022276 #FOAvip English Wikipedia <ref>{{Cite pmid|32022276}}</ref> Immunoinformatics-aided identification of T cell and B cell epitopes in the surface glycoprotein of 2019-nCoV #MMPMID32022276 Baruah V; Bose S J Med Virol 2020[May]; 92 (5): 495-500 PMID32022276show ga The 2019 novel coronavirus (2019-nCoV) outbreak has caused a large number of deaths with thousands of confirmed cases worldwide, especially in East Asia. This study took an immunoinformatics approach to identify significant cytotoxic T lymphocyte (CTL) and B cell epitopes in the 2019-nCoV surface glycoprotein. Also, interactions between identified CTL epitopes and their corresponding major histocompatibility complex (MHC) class I supertype representatives prevalent in China were studied by molecular dynamics simulations. We identified five CTL epitopes, three sequential B cell epitopes and five discontinuous B cell epitopes in the viral surface glycoprotein. Also, during simulations, the CTL epitopes were observed to be binding MHC class I peptide-binding grooves via multiple contacts, with continuous hydrogen bonds and salt bridge anchors, indicating their potential in generating immune responses. Some of these identified epitopes can be potential candidates for the development of 2019-nCoV vaccines. |*Computational Biology[MESH] |Betacoronavirus/*immunology[MESH] |COVID-19[MESH] |China[MESH] |Coronavirus Infections[MESH] |Epitopes, B-Lymphocyte/*immunology[MESH] |Epitopes, T-Lymphocyte/*immunology[MESH] |Histocompatibility Antigens Class I/*immunology[MESH] |Humans[MESH] |Molecular Dynamics Simulation[MESH] |Pneumonia, Viral[MESH] |Protein Structure, Tertiary[MESH] |SARS-CoV-2[MESH]Immunoinformatics-aided identification of T cell and B cell epitopes i(epmc).pdf DeepDyve Pubget Overpricing