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10.1096/fj.201902455R http://scihub22266oqcxt.onion/10.1096/fj.201902455R 32017270!7163995!32017270     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       FASEB+J 2020 ; 34 (3): 4653-4669 Nephropedia Template TP {{tp|p=32017270|t=2020. Dynamics of transmissible gastroenteritis virus internalization unraveled by single-virus tracking in live cells |pdf=|usr=}}{{32017270}} gab.com Text Dynamics of transmissible gastroenteritis virus internalization unraveled by single-virus tracking in live cells JO: FASEB J http://www.kidney.de/pget.php?&tw=1&pmid=32017270 #FOAvip Transmissible gastroenteritis virus (TGEV) is a swine enteropathogenic coronavirus that causes significant economic losses in swine industry. Current studies on TGEV internalization mainly focus on viral receptors, but the internalization mechanism is still unclear. In this study, we used single-virus tracking to obtain the detailed insights into the dynamic events of the TGEV internalization and depict the whole sequential process. We observed that TGEVs could be internalized through clathrin- and caveolae-mediated endocytosis, and the internalization of TGEVs was almost completed within ~2 minutes after TGEVs attached to the cell membrane. Furthermore, the interactions of TGEVs with actin and dynamin 2 in real time during the TGEV internalization were visualized. To our knowledge, this is the first report that single-virus tracking technique is used to visualize the entire dynamic process of the TGEV internalization: before the TGEV internalization, with the assistance of actin, clathrin, and caveolin 1 would gather around the virus to form the vesicle containing the TGEV, and after ~60 seconds, dynamin 2 would be recruited to promote membrane fission. These results demonstrate that TGEVs enter ST cells via clathrin- and caveolae-mediated endocytic, actin-dependent, and dynamin 2-dependent pathways. Twit Text FOAVip Dynamics of transmissible gastroenteritis virus internalization unraveled by single-virus tracking in live cells ????FASEB J http://www.kidney.de/pget.php?&tw=1&pmid=32017270 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32017270 #FOAvip English Wikipedia <ref>{{Cite pmid|32017270}}</ref> Dynamics of transmissible gastroenteritis virus internalization unraveled by single-virus tracking in live cells #MMPMID32017270 Wang J; Li Y; Wang S; Liu F FASEB J 2020[Mar]; 34 (3): 4653-4669 PMID32017270show ga Transmissible gastroenteritis virus (TGEV) is a swine enteropathogenic coronavirus that causes significant economic losses in swine industry. Current studies on TGEV internalization mainly focus on viral receptors, but the internalization mechanism is still unclear. In this study, we used single-virus tracking to obtain the detailed insights into the dynamic events of the TGEV internalization and depict the whole sequential process. We observed that TGEVs could be internalized through clathrin- and caveolae-mediated endocytosis, and the internalization of TGEVs was almost completed within ~2 minutes after TGEVs attached to the cell membrane. Furthermore, the interactions of TGEVs with actin and dynamin 2 in real time during the TGEV internalization were visualized. To our knowledge, this is the first report that single-virus tracking technique is used to visualize the entire dynamic process of the TGEV internalization: before the TGEV internalization, with the assistance of actin, clathrin, and caveolin 1 would gather around the virus to form the vesicle containing the TGEV, and after ~60 seconds, dynamin 2 would be recruited to promote membrane fission. These results demonstrate that TGEVs enter ST cells via clathrin- and caveolae-mediated endocytic, actin-dependent, and dynamin 2-dependent pathways. |Actins/metabolism[MESH] |Animals[MESH] |Caveolae/metabolism[MESH] |Caveolin 1/metabolism[MESH] |Cell Line[MESH] |Cell Membrane/metabolism/physiology/virology[MESH] |Clathrin/metabolism[MESH] |Dynamin II/metabolism[MESH] |Endocytosis/physiology[MESH] |Gastroenteritis, Transmissible, of Swine/*metabolism/*virology[MESH] |Membrane Fusion/physiology[MESH] |Swine[MESH] |Transmissible gastroenteritis virus/*pathogenicity[MESH]Dynamics of transmissible gastroenteritis virus internalization unrave(epmc).pdf DeepDyve Pubget Overpricing