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  • A pneumonia outbreak associated with a new coronavirus of probable bat origin #MMPMID32015507
  • Zhou P; Yang XL; Wang XG; Hu B; Zhang L; Zhang W; Si HR; Zhu Y; Li B; Huang CL; Chen HD; Chen J; Luo Y; Guo H; Jiang RD; Liu MQ; Chen Y; Shen XR; Wang X; Zheng XS; Zhao K; Chen QJ; Deng F; Liu LL; Yan B; Zhan FX; Wang YY; Xiao GF; Shi ZL
  • Nature 2020[Mar]; 579 (7798): 270-273 PMID32015507show ga
  • Since the outbreak of severe acute respiratory syndrome (SARS) 18 years ago, a large number of SARS-related coronaviruses (SARSr-CoVs) have been discovered in their natural reservoir host, bats(1-4). Previous studies have shown that some bat SARSr-CoVs have the potential to infect humans(5-7). Here we report the identification and characterization of a new coronavirus (2019-nCoV), which caused an epidemic of acute respiratory syndrome in humans in Wuhan, China. The epidemic, which started on 12 December 2019, had caused 2,794 laboratory-confirmed infections including 80 deaths by 26 January 2020. Full-length genome sequences were obtained from five patients at an early stage of the outbreak. The sequences are almost identical and share 79.6% sequence identity to SARS-CoV. Furthermore, we show that 2019-nCoV is 96% identical at the whole-genome level to a bat coronavirus. Pairwise protein sequence analysis of seven conserved non-structural proteins domains show that this virus belongs to the species of SARSr-CoV. In addition, 2019-nCoV virus isolated from the bronchoalveolar lavage fluid of a critically ill patient could be neutralized by sera from several patients. Notably, we confirmed that 2019-nCoV uses the same cell entry receptor-angiotensin converting enzyme II (ACE2)-as SARS-CoV.
  • |*Disease Outbreaks[MESH]
  • |Angiotensin-Converting Enzyme 2[MESH]
  • |Animals[MESH]
  • |Antibodies, Viral/blood[MESH]
  • |Betacoronavirus/*classification/*genetics/metabolism/ultrastructure[MESH]
  • |COVID-19[MESH]
  • |Cell Line[MESH]
  • |China/epidemiology[MESH]
  • |Chiroptera/*virology[MESH]
  • |Chlorocebus aethiops[MESH]
  • |Coronavirus Infections/*epidemiology/*virology[MESH]
  • |Female[MESH]
  • |Genome, Viral/genetics[MESH]
  • |Humans[MESH]
  • |Male[MESH]
  • |Peptidyl-Dipeptidase A/metabolism[MESH]
  • |Phylogeny[MESH]
  • |Pneumonia, Viral/*epidemiology/*virology[MESH]
  • |SARS Virus/classification/genetics[MESH]
  • |SARS-CoV-2[MESH]
  • |Sequence Homology, Nucleic Acid[MESH]
  • |Severe Acute Respiratory Syndrome[MESH]
  • |Vero Cells[MESH]

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  • suck abstract from ncbi

    270 7798.579 2020