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10.7554/eLife.48401 http://scihub22266oqcxt.onion/10.7554/eLife.48401 32011232!7064339!32011232     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Elife 2020 ; 9 (ä): ä Nephropedia Template TP {{tp|p=32011232|t=2020. Accelerated viral dynamics in bat cell lines, with implications for zoonotic emergence |pdf=|usr=}}{{32011232}} gab.com Text Accelerated viral dynamics in bat cell lines, with implications for zoonotic emergence JO: Elife http://www.kidney.de/pget.php?&tw=1&pmid=32011232 #FOAvip Bats host virulent zoonotic viruses without experiencing disease. A mechanistic understanding of the impact of bats' virus hosting capacities, including uniquely constitutive immune pathways, on cellular-scale viral dynamics is needed to elucidate zoonotic emergence. We carried out virus infectivity assays on bat cell lines expressing induced and constitutive immune phenotypes, then developed a theoretical model of our in vitro system, which we fit to empirical data. Best fit models recapitulated expected immune phenotypes for representative cell lines, supporting robust antiviral defenses in bat cells that correlated with higher estimates for within-host viral propagation rates. In general, heightened immune responses limit pathogen-induced cellular morbidity, which can facilitate the establishment of rapidly-propagating persistent infections within-host. Rapidly-transmitting viruses that have evolved with bat immune systems will likely cause enhanced virulence following emergence into secondary hosts with immune systems that diverge from those unique to bats. Twit Text FOAVip Accelerated viral dynamics in bat cell lines, with implications for zoonotic emergence ????Elife http://www.kidney.de/pget.php?&tw=1&pmid=32011232 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32011232 #FOAvip English Wikipedia <ref>{{Cite pmid|32011232}}</ref> Accelerated viral dynamics in bat cell lines, with implications for zoonotic emergence #MMPMID32011232 Brook CE; Boots M; Chandran K; Dobson AP; Drosten C; Graham AL; Grenfell BT; Muller MA; Ng M; Wang LF; van Leeuwen A Elife 2020[Feb]; 9 (ä): ä PMID32011232show ga Bats host virulent zoonotic viruses without experiencing disease. A mechanistic understanding of the impact of bats' virus hosting capacities, including uniquely constitutive immune pathways, on cellular-scale viral dynamics is needed to elucidate zoonotic emergence. We carried out virus infectivity assays on bat cell lines expressing induced and constitutive immune phenotypes, then developed a theoretical model of our in vitro system, which we fit to empirical data. Best fit models recapitulated expected immune phenotypes for representative cell lines, supporting robust antiviral defenses in bat cells that correlated with higher estimates for within-host viral propagation rates. In general, heightened immune responses limit pathogen-induced cellular morbidity, which can facilitate the establishment of rapidly-propagating persistent infections within-host. Rapidly-transmitting viruses that have evolved with bat immune systems will likely cause enhanced virulence following emergence into secondary hosts with immune systems that diverge from those unique to bats. |Animals[MESH] |Cell Line[MESH] |Chiroptera/immunology/*virology[MESH] |Disease Reservoirs/*veterinary/virology[MESH] |Host Microbial Interactions[MESH] |Humans[MESH] |Immunity, Cellular[MESH] |Kinetics[MESH] |Models, Biological[MESH] |Phenotype[MESH] |Risk Assessment[MESH] |Virulence[MESH] |Virus Diseases/immunology/transmission/*veterinary/virology[MESH] |Viruses/*growth & development/immunology/pathogenicity[MESH]Accelerated viral dynamics in bat cell lines, with implications for zo(epmc).pdf DeepDyve Pubget Overpricing