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10.1080/22221751.2020.1717999 http://scihub22266oqcxt.onion/10.1080/22221751.2020.1717999 31996093!7034077!31996093     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\31996093.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Emerg+Microbes+Infect 2020 ; 9 (1): 246-255 Nephropedia Template TP {{tp|p=31996093|t=2020. Discovery of a subgenotype of human coronavirus NL63 associated with severe lower respiratory tract infection in China, 2018 |pdf=|usr=}}{{31996093}} gab.com Text Discovery of a subgenotype of human coronavirus NL63 associated with severe lower respiratory tract infection in China, 2018 JO: Emerg Microbes Infect http://www.kidney.de/pget.php?&tw=1&pmid=31996093 #FOAvip Human coronavirus NL63 (HCoV-NL63) is primarily associated with common cold in children, elderly and immunocompromised individuals. Outbreaks caused by HCoV-NL63 are rare. Here we report a cluster of HCoV-NL63 cases with severe lower respiratory tract infection that arose in Guangzhou, China, in 2018. Twenty-three hospitalized children were confirmed to be HCoV-NL63 positive, and most of whom were hospitalized with severe pneumonia or acute bronchitis. Whole genomes of HCoV-NL63 were obtained using next-generation sequencing. Phylogenetic and single amino acid polymorphism analyses showed that this outbreak was associated with two subgenotypes (C3 and B) of HCoV-NL63. Half of patients were identified to be related to a new subgenotype C3. One unique amino acid mutation at I507 L in spike protein receptor binding domain (RBD) was detected, which segregated this subgenotype C3 from other known subgenotypes. Pseudotyped virus bearing the I507 L mutation in RBD showed enhanced entry into host cells as compared to the prototype virus. This study proved that HCoV-NL63 was undergoing continuous mutation and has the potential to cause severe lower respiratory disease in humans. Twit Text FOAVip Discovery of a subgenotype of human coronavirus NL63 associated with severe lower respiratory tract infection in China, 2018 ????Emerg Microbes Infect http://www.kidney.de/pget.php?&tw=1&pmid=31996093 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=31996093 #FOAvip English Wikipedia <ref>{{Cite pmid|31996093}}</ref> Discovery of a subgenotype of human coronavirus NL63 associated with severe lower respiratory tract infection in China, 2018 #MMPMID31996093 Wang Y; Li X; Liu W; Gan M; Zhang L; Wang J; Zhang Z; Zhu A; Li F; Sun J; Zhang G; Zhuang Z; Luo J; Chen D; Qiu S; Zhang L; Xu D; Mok CKP; Zhang F; Zhao J; Zhou R; Zhao J Emerg Microbes Infect 2020[]; 9 (1): 246-255 PMID31996093show ga Human coronavirus NL63 (HCoV-NL63) is primarily associated with common cold in children, elderly and immunocompromised individuals. Outbreaks caused by HCoV-NL63 are rare. Here we report a cluster of HCoV-NL63 cases with severe lower respiratory tract infection that arose in Guangzhou, China, in 2018. Twenty-three hospitalized children were confirmed to be HCoV-NL63 positive, and most of whom were hospitalized with severe pneumonia or acute bronchitis. Whole genomes of HCoV-NL63 were obtained using next-generation sequencing. Phylogenetic and single amino acid polymorphism analyses showed that this outbreak was associated with two subgenotypes (C3 and B) of HCoV-NL63. Half of patients were identified to be related to a new subgenotype C3. One unique amino acid mutation at I507 L in spike protein receptor binding domain (RBD) was detected, which segregated this subgenotype C3 from other known subgenotypes. Pseudotyped virus bearing the I507 L mutation in RBD showed enhanced entry into host cells as compared to the prototype virus. This study proved that HCoV-NL63 was undergoing continuous mutation and has the potential to cause severe lower respiratory disease in humans. |*Coronavirus Infections[MESH] |Child, Preschool[MESH] |China[MESH] |Coronavirus NL63, Human/*genetics/isolation & purification[MESH] |Genotype[MESH] |Humans[MESH] |Infant[MESH] |Phylogeny[MESH]Discovery of a subgenotype of human coronavirus NL63 associated with s(epmc).pdf DeepDyve Pubget Overpricing