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10.1080/22221751.2020.1719902

http://scihub22266oqcxt.onion/10.1080/22221751.2020.1719902
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31987001!7067204!31987001
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suck abstract from ncbi

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  • Genomic characterization of the 2019 novel human-pathogenic coronavirus isolated from a patient with atypical pneumonia after visiting Wuhan #MMPMID31987001
  • Chan JF; Kok KH; Zhu Z; Chu H; To KK; Yuan S; Yuen KY
  • Emerg Microbes Infect 2020[]; 9 (1): 221-236 PMID31987001show ga
  • A mysterious outbreak of atypical pneumonia in late 2019 was traced to a seafood wholesale market in Wuhan of China. Within a few weeks, a novel coronavirus tentatively named as 2019 novel coronavirus (2019-nCoV) was announced by the World Health Organization. We performed bioinformatics analysis on a virus genome from a patient with 2019-nCoV infection and compared it with other related coronavirus genomes. Overall, the genome of 2019-nCoV has 89% nucleotide identity with bat SARS-like-CoVZXC21 and 82% with that of human SARS-CoV. The phylogenetic trees of their orf1a/b, Spike, Envelope, Membrane and Nucleoprotein also clustered closely with those of the bat, civet and human SARS coronaviruses. However, the external subdomain of Spike's receptor binding domain of 2019-nCoV shares only 40% amino acid identity with other SARS-related coronaviruses. Remarkably, its orf3b encodes a completely novel short protein. Furthermore, its new orf8 likely encodes a secreted protein with an alpha-helix, following with a beta-sheet(s) containing six strands. Learning from the roles of civet in SARS and camel in MERS, hunting for the animal source of 2019-nCoV and its more ancestral virus would be important for understanding the origin and evolution of this novel lineage B betacoronavirus. These findings provide the basis for starting further studies on the pathogenesis, and optimizing the design of diagnostic, antiviral and vaccination strategies for this emerging infection.
  • |*Genome, Viral[MESH]
  • |Amino Acid Sequence[MESH]
  • |Betacoronavirus/*genetics/isolation & purification[MESH]
  • |COVID-19[MESH]
  • |China[MESH]
  • |Coronavirus Infections/*virology[MESH]
  • |Humans[MESH]
  • |Phylogeny[MESH]
  • |Pneumonia, Viral/*virology[MESH]
  • |SARS-CoV-2[MESH]
  • |Sequence Analysis, Protein[MESH]
  • |Travel[MESH]
  • |Viral Proteins/chemistry/genetics[MESH]


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  • suck abstract from ncbi

    221 1.9 2020