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10.1177/1753425919838322 http://scihub22266oqcxt.onion/10.1177/1753425919838322 31955624!6974875!31955624     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Innate+Immun 2020 ; 26 (1): 15-25 Nephropedia Template TP {{tp|p=31955624|t=2020. Molecular regulation of TLR signaling in health and disease: mechano-regulation of macrophages and TLR signaling |pdf=|usr=}}{{31955624}} gab.com Text Molecular regulation of TLR signaling in health and disease: mechano-regulation of macrophages and TLR signaling JO: Innate Immun http://www.kidney.de/pget.php?&tw=1&pmid=31955624 #FOAvip Immune cells encounter tissues with vastly different biochemical and physical characteristics. Much of the research emphasis has focused on the role of cytokines and chemokines in regulating immune cell function, but the role of the physical microenvironment has received considerably less attention. The tissue mechanics, or stiffness, of healthy tissues varies dramatically from soft adipose tissue and brain to stiff cartilage and bone. Tissue mechanics also change due to fibrosis and with diseases such as atherosclerosis or cancer. The process by which cells sense and respond to their physical microenvironment is called mechanotransduction. Here we review mechanotransduction in immunologically important diseases and how physical characteristics of tissues regulate immune cell function, with a specific emphasis on mechanoregulation of macrophages and TLR signaling. Twit Text FOAVip Molecular regulation of TLR signaling in health and disease: mechano-regulation of macrophages and TLR signaling ????Innate Immun http://www.kidney.de/pget.php?&tw=1&pmid=31955624 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=31955624 #FOAvip English Wikipedia <ref>{{Cite pmid|31955624}}</ref> Molecular regulation of TLR signaling in health and disease: mechano-regulation of macrophages and TLR signaling #MMPMID31955624 Gruber EJ; Leifer CA Innate Immun 2020[Jan]; 26 (1): 15-25 PMID31955624show ga Immune cells encounter tissues with vastly different biochemical and physical characteristics. Much of the research emphasis has focused on the role of cytokines and chemokines in regulating immune cell function, but the role of the physical microenvironment has received considerably less attention. The tissue mechanics, or stiffness, of healthy tissues varies dramatically from soft adipose tissue and brain to stiff cartilage and bone. Tissue mechanics also change due to fibrosis and with diseases such as atherosclerosis or cancer. The process by which cells sense and respond to their physical microenvironment is called mechanotransduction. Here we review mechanotransduction in immunologically important diseases and how physical characteristics of tissues regulate immune cell function, with a specific emphasis on mechanoregulation of macrophages and TLR signaling. |Animals[MESH] |Atherosclerosis/*metabolism[MESH] |Cellular Microenvironment[MESH] |Humans[MESH] |Immune System Diseases[MESH] |Macrophages/immunology/*metabolism[MESH] |Mechanotransduction, Cellular/*immunology[MESH] |Neoplasms/*metabolism[MESH] |Signal Transduction[MESH]Molecular regulation of TLR signaling in health and disease: mechano-r(epmc).pdf DeepDyve Pubget Overpricing