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10.2478/acph-2020-0024 http://scihub22266oqcxt.onion/10.2478/acph-2020-0024 31955138!ä!31955138 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Acta+Pharm 2020 ; 70 (2): 145-159 Nephropedia Template TP {{tp|p=31955138|t=2020. Design, synthesis and molecular docking of novel triazole derivatives as potential CoV helicase inhibitors |pdf=|usr=}}{{31955138}} gab.com Text Design, synthesis and molecular docking of novel triazole derivatives as potential CoV helicase inhibitors JO: Acta Pharm http://www.kidney.de/pget.php?&tw=1&pmid=31955138 #FOAvip Middle East respiratory syndrome coronavirus (MERS-CoV) had emerged and spread because of the worldwide travel and inefficient healthcare provided for the infected patients in several countries. Herein we investigated the anti-MERS-CoV activity of newly synthesized sixteen halogenated triazole compounds through the inhibition of helicase activity using the FRET assay. All new compounds underwent justification for their target structures via microanalytical and spectral data. SAR studies were performed. Biological results revealed that the most potent compounds were 4-(cyclopent-1-en-3-ylamino)-5-(2-(4-iodophenyl)hydrazinyl)-4H-1,2,4-triazole-3-thiol (16) and 4-(cyclopent-1-en-3-ylamino)-5-[2-(4-chlorophenyl)hydrazinyl]-4H-1,2,4-triazole-3-thiol (12). In silico molecular docking of the most potent compounds was performed to the active binding site of MERS-CoV helicase nsp13. Molecular docking results are in agreement with experimental findings. Twit Text FOAVip Design, synthesis and molecular docking of novel triazole derivatives as potential CoV helicase inhibitors ????Acta Pharm http://www.kidney.de/pget.php?&tw=1&pmid=31955138 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=31955138 #FOAvip English Wikipedia <ref>{{Cite pmid|31955138}}</ref> Design, synthesis and molecular docking of novel triazole derivatives as potential CoV helicase inhibitors #MMPMID31955138 Zaher NH; Mostafa MI; Altaher AY Acta Pharm 2020[Jun]; 70 (2): 145-159 PMID31955138show ga Middle East respiratory syndrome coronavirus (MERS-CoV) had emerged and spread because of the worldwide travel and inefficient healthcare provided for the infected patients in several countries. Herein we investigated the anti-MERS-CoV activity of newly synthesized sixteen halogenated triazole compounds through the inhibition of helicase activity using the FRET assay. All new compounds underwent justification for their target structures via microanalytical and spectral data. SAR studies were performed. Biological results revealed that the most potent compounds were 4-(cyclopent-1-en-3-ylamino)-5-(2-(4-iodophenyl)hydrazinyl)-4H-1,2,4-triazole-3-thiol (16) and 4-(cyclopent-1-en-3-ylamino)-5-[2-(4-chlorophenyl)hydrazinyl]-4H-1,2,4-triazole-3-thiol (12). In silico molecular docking of the most potent compounds was performed to the active binding site of MERS-CoV helicase nsp13. Molecular docking results are in agreement with experimental findings. |*Computer-Aided Design[MESH] |*Drug Design[MESH] |*Molecular Docking Simulation[MESH] |Animals[MESH] |Antiviral Agents/chemical synthesis/metabolism/*pharmacology[MESH] |Coronavirus Infections/*drug therapy/virology[MESH] |DNA Helicases/*antagonists & inhibitors/chemistry/metabolism[MESH] |Enzyme Inhibitors/chemical synthesis/metabolism/*pharmacology[MESH] |Humans[MESH] |Middle East Respiratory Syndrome Coronavirus/*drug effects/enzymology/growth & development[MESH] |Molecular Structure[MESH] |Protein Binding[MESH] |Structure-Activity Relationship[MESH] |Triazoles/chemical synthesis/metabolism/*pharmacology[MESH] |Viral Proteins/*antagonists & inhibitors/chemistry/metabolism[MESH]Design, synthesis and molecular docking of novel triazole derivatives (epmc).pdf DeepDyve Pubget Overpricing