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10.1080/01902148.2020.1711830 http://scihub22266oqcxt.onion/10.1080/01902148.2020.1711830 31931639!ä!31931639 Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=31931639&cmd=llinks): Failed to open stream: HTTP request failed! 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Dioscin alleviates lipopolysaccharide-induced acute lung injury through suppression of TLR4 signaling pathways |pdf=|usr=}}{{31931639}} gab.com Text Dioscin alleviates lipopolysaccharide-induced acute lung injury through suppression of TLR4 signaling pathways JO: Exp Lung Res http://www.kidney.de/pget.php?&tw=1&pmid=31931639 #FOAvip Aim: Acute lung injury (ALI) is a life-threatening inflammatory syndrome that lacks an effective therapy. Dioscin, a natural steroid saponin isolated from a variety of herbs, could serve as an anti-inflammatory agent, as suggested in previous reports. The purpose of this study was to explore the effects of dioscin on lipopolysaccharide (LPS)-induced ALI and validate the potential mechanisms.Materials and Methods: An ALI model was induced by intratracheal administration of LPS. Dioscin (20, 40, and 80 mg/kg) was administered intragastrically once daily for seven consecutive days prior to LPS challenge.Results: Our data revealed that dioscin significantly suppressed LPS-induced lung pathological changes, pulmonary capillary permeability, pulmonary edema, inflammatory cell infiltration, myeloperoxidase (MPO) activity, and cytokine production, including tumor necrosis factor (TNF)-alpha, interleukin (IL)-6, and keratinocyte chemoattractant (KC). Moreover, dioscin inhibited LPS-induced nuclear factor-kappaB (NF-kappaB) activation as well as Toll-like receptor 4 (TLR4) expression.Conclusions: In brief, the results indicated that dioscin alleviates LPS-induced ALI through suppression of TLR4 signaling pathways. Twit Text FOAVip Dioscin alleviates lipopolysaccharide-induced acute lung injury through suppression of TLR4 signaling pathways ????Exp Lung Res http://www.kidney.de/pget.php?&tw=1&pmid=31931639 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=31931639 #FOAvip English Wikipedia <ref>{{Cite pmid|31931639}}</ref> Dioscin alleviates lipopolysaccharide-induced acute lung injury through suppression of TLR4 signaling pathways #MMPMID31931639 Wang C; Li Q; Li T Exp Lung Res 2020[Feb]; 46 (1-2): 11-22 PMID31931639show ga Aim: Acute lung injury (ALI) is a life-threatening inflammatory syndrome that lacks an effective therapy. Dioscin, a natural steroid saponin isolated from a variety of herbs, could serve as an anti-inflammatory agent, as suggested in previous reports. The purpose of this study was to explore the effects of dioscin on lipopolysaccharide (LPS)-induced ALI and validate the potential mechanisms.Materials and Methods: An ALI model was induced by intratracheal administration of LPS. Dioscin (20, 40, and 80 mg/kg) was administered intragastrically once daily for seven consecutive days prior to LPS challenge.Results: Our data revealed that dioscin significantly suppressed LPS-induced lung pathological changes, pulmonary capillary permeability, pulmonary edema, inflammatory cell infiltration, myeloperoxidase (MPO) activity, and cytokine production, including tumor necrosis factor (TNF)-alpha, interleukin (IL)-6, and keratinocyte chemoattractant (KC). Moreover, dioscin inhibited LPS-induced nuclear factor-kappaB (NF-kappaB) activation as well as Toll-like receptor 4 (TLR4) expression.Conclusions: In brief, the results indicated that dioscin alleviates LPS-induced ALI through suppression of TLR4 signaling pathways. |A549 Cells[MESH] |Acute Lung Injury/*chemically induced/*drug therapy/metabolism[MESH] |Animals[MESH] |Capillary Permeability/drug effects[MESH] |Chemotactic Factors/metabolism[MESH] |Cytokines/metabolism[MESH] |Diosgenin/*analogs & derivatives/pharmacology[MESH] |Humans[MESH] |Inflammation/drug therapy/metabolism[MESH] |Interleukin-6/metabolism[MESH] |Lipopolysaccharides/*pharmacology[MESH] |Lung/drug effects/metabolism[MESH] |Male[MESH] |Mice[MESH] |Mice, Inbred BALB C[MESH] |NF-kappa B/metabolism[MESH] |Peroxidase/metabolism[MESH] |Pulmonary Edema/drug therapy/metabolism[MESH] |Signal Transduction/*drug effects[MESH] |Toll-Like Receptor 4/*metabolism[MESH]Dioscin alleviates lipopolysaccharide-induced acute lung injury throug(epmc).pdf DeepDyve Pubget Overpricing