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10.1038/s41598-019-55995-x http://scihub22266oqcxt.onion/10.1038/s41598-019-55995-x 31863073!6925205!31863073     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Rep 2019 ; 9 (1): 19540 Nephropedia Template TP {{tp|p=31863073|t=2019. Deletion of the serine protease CAP2/Tmprss4 leads to dysregulated renal water handling upon dietary potassium depletion |pdf=|usr=}}{{31863073}} gab.com Text Deletion of the serine protease CAP2/Tmprss4 leads to dysregulated renal water handling upon dietary potassium depletion JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=31863073 #FOAvip The kidney needs to adapt daily to variable dietary K(+) contents via various mechanisms including diuretic, acid-base and hormonal changes that are still not fully understood. In this study, we demonstrate that following a K(+)-deficient diet in wildtype mice, the serine protease CAP2/Tmprss4 is upregulated in connecting tubule and cortical collecting duct and also localizes to the medulla and transitional epithelium of the papilla and minor calyx. Male CAP2/Tmprss4 knockout mice display altered water handling and urine osmolality, enhanced vasopressin response leading to upregulated adenylate cyclase 6 expression and cAMP overproduction, and subsequently greater aquaporin 2 (AQP2) and Na(+)-K(+)-2Cl(-) cotransporter 2 (NKCC2) expression following K(+)-deficient diet. Urinary acidification coincides with significantly increased H(+),K(+)-ATPase type 2 (HKA2) mRNA and protein expression, and decreased calcium and phosphate excretion. This is accompanied by increased glucocorticoid receptor (GR) protein levels and reduced 11beta-hydroxysteroid dehydrogenase 2 activity in knockout mice. Strikingly, genetic nephron-specific deletion of GR leads to the mirrored phenotype of CAP2/Tmprss4 knockouts, including increased water intake and urine output, urinary alkalinisation, downregulation of HKA2, AQP2 and NKCC2. Collectively, our data unveil a novel role of the serine protease CAP2/Tmprss4 and GR on renal water handling upon dietary K(+) depletion. Twit Text FOAVip Deletion of the serine protease CAP2/Tmprss4 leads to dysregulated renal water handling upon dietary potassium depletion ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=31863073 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=31863073 #FOAvip English Wikipedia <ref>{{Cite pmid|31863073}}</ref> Deletion of the serine protease CAP2/Tmprss4 leads to dysregulated renal water handling upon dietary potassium depletion #MMPMID31863073 Keppner A; Maric D; Sergi C; Ansermet C; De Bellis D; Kratschmar DV; Canonica J; Klusonova P; Fenton RA; Odermatt A; Crambert G; Hoogewijs D; Hummler E Sci Rep 2019[Dec]; 9 (1): 19540 PMID31863073show ga The kidney needs to adapt daily to variable dietary K(+) contents via various mechanisms including diuretic, acid-base and hormonal changes that are still not fully understood. In this study, we demonstrate that following a K(+)-deficient diet in wildtype mice, the serine protease CAP2/Tmprss4 is upregulated in connecting tubule and cortical collecting duct and also localizes to the medulla and transitional epithelium of the papilla and minor calyx. Male CAP2/Tmprss4 knockout mice display altered water handling and urine osmolality, enhanced vasopressin response leading to upregulated adenylate cyclase 6 expression and cAMP overproduction, and subsequently greater aquaporin 2 (AQP2) and Na(+)-K(+)-2Cl(-) cotransporter 2 (NKCC2) expression following K(+)-deficient diet. Urinary acidification coincides with significantly increased H(+),K(+)-ATPase type 2 (HKA2) mRNA and protein expression, and decreased calcium and phosphate excretion. This is accompanied by increased glucocorticoid receptor (GR) protein levels and reduced 11beta-hydroxysteroid dehydrogenase 2 activity in knockout mice. Strikingly, genetic nephron-specific deletion of GR leads to the mirrored phenotype of CAP2/Tmprss4 knockouts, including increased water intake and urine output, urinary alkalinisation, downregulation of HKA2, AQP2 and NKCC2. Collectively, our data unveil a novel role of the serine protease CAP2/Tmprss4 and GR on renal water handling upon dietary K(+) depletion. |11-beta-Hydroxysteroid Dehydrogenase Type 2/genetics/*metabolism[MESH] |Adaptor Proteins, Signal Transducing/genetics/*metabolism[MESH] |Animals[MESH] |Aquaporin 2/*metabolism[MESH] |Blotting, Western[MESH] |Electrophoresis, Polyacrylamide Gel[MESH] |Enzyme-Linked Immunosorbent Assay[MESH] |Kidney/metabolism[MESH] |Male[MESH] |Membrane Proteins/genetics/metabolism[MESH] |Mice[MESH] |Potassium, Dietary/metabolism[MESH] |Receptors, Glucocorticoid/metabolism[MESH] |Reverse Transcriptase Polymerase Chain Reaction[MESH] |Serine Endopeptidases/genetics/metabolism[MESH]Deletion of the serine protease CAP2/Tmprss4 leads to dysregulated ren(epmc).pdf DeepDyve Pubget Overpricing