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10.1038/s41467-019-13659-4 http://scihub22266oqcxt.onion/10.1038/s41467-019-13659-4 31852899!6920372!31852899     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\31852899.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Nat+Commun 2019 ; 10 (1): 5770 Nephropedia Template TP {{tp|p=31852899|t=2019. SKP2 attenuates autophagy through Beclin1-ubiquitination and its inhibition reduces MERS-Coronavirus infection |pdf=|usr=}}{{31852899}} gab.com Text SKP2 attenuates autophagy through Beclin1-ubiquitination and its inhibition reduces MERS-Coronavirus infection JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=31852899 #FOAvip Autophagy is an essential cellular process affecting virus infections and other diseases and Beclin1 (BECN1) is one of its key regulators. Here, we identified S-phase kinase-associated protein 2 (SKP2) as E3 ligase that executes lysine-48-linked poly-ubiquitination of BECN1, thus promoting its proteasomal degradation. SKP2 activity is regulated by phosphorylation in a hetero-complex involving FKBP51, PHLPP, AKT1, and BECN1. Genetic or pharmacological inhibition of SKP2 decreases BECN1 ubiquitination, decreases BECN1 degradation and enhances autophagic flux. Middle East respiratory syndrome coronavirus (MERS-CoV) multiplication results in reduced BECN1 levels and blocks the fusion of autophagosomes and lysosomes. Inhibitors of SKP2 not only enhance autophagy but also reduce the replication of MERS-CoV up to 28,000-fold. The SKP2-BECN1 link constitutes a promising target for host-directed antiviral drugs and possibly other autophagy-sensitive conditions. Twit Text FOAVip SKP2 attenuates autophagy through Beclin1-ubiquitination and its inhibition reduces MERS-Coronavirus infection ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=31852899 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=31852899 #FOAvip English Wikipedia <ref>{{Cite pmid|31852899}}</ref> SKP2 attenuates autophagy through Beclin1-ubiquitination and its inhibition reduces MERS-Coronavirus infection #MMPMID31852899 Gassen NC; Niemeyer D; Muth D; Corman VM; Martinelli S; Gassen A; Hafner K; Papies J; Mosbauer K; Zellner A; Zannas AS; Herrmann A; Holsboer F; Brack-Werner R; Boshart M; Muller-Myhsok B; Drosten C; Muller MA; Rein T Nat Commun 2019[Dec]; 10 (1): 5770 PMID31852899show ga Autophagy is an essential cellular process affecting virus infections and other diseases and Beclin1 (BECN1) is one of its key regulators. Here, we identified S-phase kinase-associated protein 2 (SKP2) as E3 ligase that executes lysine-48-linked poly-ubiquitination of BECN1, thus promoting its proteasomal degradation. SKP2 activity is regulated by phosphorylation in a hetero-complex involving FKBP51, PHLPP, AKT1, and BECN1. Genetic or pharmacological inhibition of SKP2 decreases BECN1 ubiquitination, decreases BECN1 degradation and enhances autophagic flux. Middle East respiratory syndrome coronavirus (MERS-CoV) multiplication results in reduced BECN1 levels and blocks the fusion of autophagosomes and lysosomes. Inhibitors of SKP2 not only enhance autophagy but also reduce the replication of MERS-CoV up to 28,000-fold. The SKP2-BECN1 link constitutes a promising target for host-directed antiviral drugs and possibly other autophagy-sensitive conditions. |Animals[MESH] |Autophagy/drug effects/*immunology[MESH] |Beclin-1/*metabolism[MESH] |Chlorocebus aethiops[MESH] |Coronavirus Infections/*immunology/virology[MESH] |Gene Knockdown Techniques[MESH] |HEK293 Cells[MESH] |Humans[MESH] |Middle East Respiratory Syndrome Coronavirus/*immunology/pathogenicity[MESH] |Proteolysis/drug effects[MESH] |S-Phase Kinase-Associated Proteins/antagonists & inhibitors/genetics/*metabolism[MESH] |Ubiquitination/drug effects/immunology[MESH]SKP2 attenuates autophagy through Beclin1-ubiquitination and its inhib(epmc).pdf DeepDyve Pubget Overpricing