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10.3390/v11121154

http://scihub22266oqcxt.onion/10.3390/v11121154
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31847269!6950461!31847269
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suck abstract from ncbi


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pmid31847269      Viruses 2019 ; 11 (12): ä
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  • Antigenic and Pathogenic Characteristics of QX-Type Avian Infectious Bronchitis Virus Strains Isolated in Southwestern China #MMPMID31847269
  • Li S; Du L; Xia J; Du J; You G; Wen Y; Huang X; Zhao Q; Han X; Yan Q; Wu R; Cui M; Cao S; Huang Y
  • Viruses 2019[Dec]; 11 (12): ä PMID31847269show ga
  • The QX-type avian infectious bronchitis virus (IBV) is still a prevalent genotype in Southwestern China. To analyze the antigenicity and pathogenicity characteristics of the dominant genotype strains (QX-type), S1 gene sequence analysis, virus cross-neutralization tests, and pathogenicity test of eight QX-type IBV isolates were conducted. Sequence analysis showed that the nucleotide homology between the eight strains was high, but distantly related to H120 and 4/91 vaccine strains. Cross-neutralization tests showed that all eight strains isolated from 2015 and 2017 belonged to the same serotype, but exhibited antigenic variations over time. The pathogenicity test of the five QX-type IBV isolates showed that only three strains, CK/CH/SC/DYW/16, CK/CH/SC/MS/17, and CK/CH/SC/GH/15, had a high mortality rate with strong respiratory and renal pathogenicity, whereas CK/CH/SC/PZ/17 and CK/CH/SC/DYYJ/17 caused only mild clinical symptoms and tissue lesions. Our results indicate that the prevalent QX-type IBVs displayed antigenic variations and pathogenicity difference. These findings may provide reference for research on the evolution of IBV and vaccine preparation of infectious bronchitis (IB).
  • |Animals[MESH]
  • |Antigens, Viral/*immunology[MESH]
  • |Chickens/virology[MESH]
  • |Coronavirus Infections/*veterinary[MESH]
  • |Genome, Viral[MESH]
  • |Genotype[MESH]
  • |Immunohistochemistry[MESH]
  • |Infectious bronchitis virus/pathogenicity/*physiology[MESH]
  • |Neutralization Tests[MESH]
  • |Open Reading Frames[MESH]
  • |Phylogeny[MESH]
  • |Poultry Diseases/mortality/pathology/*virology[MESH]


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