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10.1016/j.intimp.2019.106032 http://scihub22266oqcxt.onion/10.1016/j.intimp.2019.106032 31835089!ä!31835089 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Int+Immunopharmacol 2020 ; 78 (ä): 106032 Nephropedia Template TP {{tp|p=31835089|t=2020. Methionine enkephalin inhibits influenza A virus infection through upregulating antiviral state in RAW264 7 cells |pdf=|usr=}}{{31835089}} gab.com Text Methionine enkephalin inhibits influenza A virus infection through upregulating antiviral state in RAW264 7 cells JO: Int Immunopharmacol http://www.kidney.de/pget.php?&tw=1&pmid=31835089 #FOAvip MENK, as an immune adjuvant, has potential immune-regulatory activity on innate and adaptive immune cells. The aim of this work was to investigate the antiviral effect of MENK on influenza virus-infected murine macrophage cells (RAW264.7) and its underlying mechanisms. The results showed that MENK markedly inhibited influenza A virus (H1N1) replication in pre- and post-MENK treatment, especially in pre-MENK treatment. The mechanisms exploration revealed that MENK (10?mg/mL) significantly inhibited the nucleoprotein (NP) of influenza virus and up-regulated levels of IL-6, TNF-alpha and IFN-beta compared with those in H1N1 control group. Further experiments confirmed that antiviral effects of MENK was associated with promotion of opioid receptor (MOR) as well as activation of NF-kappaB p65 inducing cellular antiviral status. The data suggest that MENK should be potential candidate for prophylactic or therapeutic treatment against H1N1 influenza virus. Twit Text FOAVip Methionine enkephalin inhibits influenza A virus infection through upregulating antiviral state in RAW264 7 cells ????Int Immunopharmacol http://www.kidney.de/pget.php?&tw=1&pmid=31835089 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=31835089 #FOAvip English Wikipedia <ref>{{Cite pmid|31835089}}</ref> Methionine enkephalin inhibits influenza A virus infection through upregulating antiviral state in RAW264 7 cells #MMPMID31835089 Tian J; Qu N; Jiao X; Wang X; Geng J; Griffin N; Shan F Int Immunopharmacol 2020[Jan]; 78 (ä): 106032 PMID31835089show ga MENK, as an immune adjuvant, has potential immune-regulatory activity on innate and adaptive immune cells. The aim of this work was to investigate the antiviral effect of MENK on influenza virus-infected murine macrophage cells (RAW264.7) and its underlying mechanisms. The results showed that MENK markedly inhibited influenza A virus (H1N1) replication in pre- and post-MENK treatment, especially in pre-MENK treatment. The mechanisms exploration revealed that MENK (10?mg/mL) significantly inhibited the nucleoprotein (NP) of influenza virus and up-regulated levels of IL-6, TNF-alpha and IFN-beta compared with those in H1N1 control group. Further experiments confirmed that antiviral effects of MENK was associated with promotion of opioid receptor (MOR) as well as activation of NF-kappaB p65 inducing cellular antiviral status. The data suggest that MENK should be potential candidate for prophylactic or therapeutic treatment against H1N1 influenza virus. |Adjuvants, Immunologic/*pharmacology/therapeutic use[MESH] |Animals[MESH] |Enkephalin, Methionine/*pharmacology/therapeutic use[MESH] |Humans[MESH] |Influenza A Virus, H1N1 Subtype/*immunology[MESH] |Influenza, Human/*drug therapy/immunology/virology[MESH] |Interferon-beta/metabolism[MESH] |Interleukin-6/metabolism[MESH] |Macrophages/*drug effects/immunology/metabolism[MESH] |Mice[MESH] |RAW 264.7 Cells[MESH] |Receptors, Opioid, mu/metabolism[MESH] |Signal Transduction/drug effects/immunology[MESH] |Transcription Factor RelA/metabolism[MESH] |Tumor Necrosis Factor-alpha/metabolism[MESH] |Up-Regulation/drug effects[MESH]Methionine enkephalin inhibits influenza A virus infection through upr(epmc).pdf DeepDyve Pubget Overpricing