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Methionine enkephalin inhibits influenza A virus infection through upregulating antiviral state in RAW264 7 cells #MMPMID31835089
Tian J; Qu N; Jiao X; Wang X; Geng J; Griffin N; Shan F
Int Immunopharmacol 2020[Jan]; 78 (?): 106032 PMID31835089show ga
MENK, as an immune adjuvant, has potential immune-regulatory activity on innate and adaptive immune cells. The aim of this work was to investigate the antiviral effect of MENK on influenza virus-infected murine macrophage cells (RAW264.7) and its underlying mechanisms. The results showed that MENK markedly inhibited influenza A virus (H1N1) replication in pre- and post-MENK treatment, especially in pre-MENK treatment. The mechanisms exploration revealed that MENK (10?mg/mL) significantly inhibited the nucleoprotein (NP) of influenza virus and up-regulated levels of IL-6, TNF-alpha and IFN-beta compared with those in H1N1 control group. Further experiments confirmed that antiviral effects of MENK was associated with promotion of opioid receptor (MOR) as well as activation of NF-kappaB p65 inducing cellular antiviral status. The data suggest that MENK should be potential candidate for prophylactic or therapeutic treatment against H1N1 influenza virus.
Int+Immunopharmacol 2020 ; 78 (?): 106032
