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10.1002/ppul.24602 http://scihub22266oqcxt.onion/10.1002/ppul.24602 31821737!7168041!31821737     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Pediatr+Pulmonol 2020 ; 55 (2): 418-425 Nephropedia Template TP {{tp|p=31821737|t=2020. New insights into pediatric community-acquired pneumonia gained from untargeted metabolomics: A preliminary study |pdf=|usr=}}{{31821737}} gab.com Text New insights into pediatric community-acquired pneumonia gained from untargeted metabolomics: A preliminary study JO: Pediatr Pulmonol http://www.kidney.de/pget.php?&tw=1&pmid=31821737 #FOAvip BACKGROUND: Available diagnostics often fail to distinguish viral from bacterial causes of pediatric community-acquired pneumonia (pCAP). Metabolomics, which aims at characterizing diseases based on their metabolic signatures, has been applied to expand pathophysiological understanding of many diseases. In this exploratory study, we used the untargeted metabolomic analysis to shed new light on the etiology of pCAP. METHODS: Liquid chromatography coupled with mass spectrometry was used to quantify the metabolite content of urine samples collected from children hospitalized for CAP of pneumococcal or viral etiology, ascertained using a conservative algorithm combining microbiological and biochemical data. RESULTS: Fifty-nine children with CAP were enrolled over 16 months. Pneumococcal and viral cases were distinguished by means of a multivariate model based on 93 metabolites, 20 of which were identified and considered as putative biomarkers. Among these, six metabolites belonged to the adrenal steroid synthesis and degradation pathway. CONCLUSIONS: This preliminary study suggests that viral and pneumococcal pneumonia differently affect the systemic metabolome, with a stronger disruption of the adrenal steroid pathway in pneumococcal pneumonia. This finding may lead to the discovery of novel diagnostic biomarkers and bring us closer to personalized therapy for pCAP. Twit Text FOAVip New insights into pediatric community-acquired pneumonia gained from untargeted metabolomics: A preliminary study ????Pediatr Pulmonol http://www.kidney.de/pget.php?&tw=1&pmid=31821737 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=31821737 #FOAvip English Wikipedia <ref>{{Cite pmid|31821737}}</ref> New insights into pediatric community-acquired pneumonia gained from untargeted metabolomics: A preliminary study #MMPMID31821737 Del Borrello G; Stocchero M; Giordano G; Pirillo P; Zanconato S; Da Dalt L; Carraro S; Esposito S; Baraldi E Pediatr Pulmonol 2020[Feb]; 55 (2): 418-425 PMID31821737show ga BACKGROUND: Available diagnostics often fail to distinguish viral from bacterial causes of pediatric community-acquired pneumonia (pCAP). Metabolomics, which aims at characterizing diseases based on their metabolic signatures, has been applied to expand pathophysiological understanding of many diseases. In this exploratory study, we used the untargeted metabolomic analysis to shed new light on the etiology of pCAP. METHODS: Liquid chromatography coupled with mass spectrometry was used to quantify the metabolite content of urine samples collected from children hospitalized for CAP of pneumococcal or viral etiology, ascertained using a conservative algorithm combining microbiological and biochemical data. RESULTS: Fifty-nine children with CAP were enrolled over 16 months. Pneumococcal and viral cases were distinguished by means of a multivariate model based on 93 metabolites, 20 of which were identified and considered as putative biomarkers. Among these, six metabolites belonged to the adrenal steroid synthesis and degradation pathway. CONCLUSIONS: This preliminary study suggests that viral and pneumococcal pneumonia differently affect the systemic metabolome, with a stronger disruption of the adrenal steroid pathway in pneumococcal pneumonia. This finding may lead to the discovery of novel diagnostic biomarkers and bring us closer to personalized therapy for pCAP. |Algorithms[MESH] |Biomarkers/metabolism[MESH] |Child[MESH] |Child, Preschool[MESH] |Community-Acquired Infections/*metabolism[MESH] |Female[MESH] |Humans[MESH] |Infant[MESH] |Male[MESH] |Metabolome[MESH] |Metabolomics[MESH] |Pneumonia, Pneumococcal/*metabolism[MESH]New insights into pediatric community-acquired pneumonia gained from u(epmc).pdf DeepDyve Pubget Overpricing