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10.1016/j.bbrc.2019.12.012 http://scihub22266oqcxt.onion/10.1016/j.bbrc.2019.12.012 31818462!7092853!31818462     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Biochem+Biophys+Res+Commun 2020 ; 522 (4): 1052-1058 Nephropedia Template TP {{tp|p=31818462|t=2020. Cephalotaxine inhibits Zika infection by impeding viral replication and stability |pdf=|usr=}}{{31818462}} gab.com Text Cephalotaxine inhibits Zika infection by impeding viral replication and stability JO: Biochem Biophys Res Commun http://www.kidney.de/pget.php?&tw=1&pmid=31818462 #FOAvip The Zika virus (ZIKV) is a mosquito-borne flavivirus that has reemerged as a serious public health problem around the world. Syndromes of infected people range from asymptomatic infections to severe neurological disorders, such as Guillain-Barre syndrome and microcephaly. Screening anti-ZIKV drugs derived from Chinese medicinal herbs is one method of identifying antiviral agents. In this paper, we report that (1) Cephalotaxine (CET), an alkaloid isolated from Cephalotaxus drupacea, was effective in inhibiting ZIKV activity in vitro (i.e., in Vero and A549 cell lines) and (2) the mechanisms which underlie these effects involve virucidal activity and a decrease in viral replication. Specifically, CET was found to decrease ZIKV RNA and viral protein expression, inhibit ZIKV replication, and inhibit ZIKV mRNA/protein production. We also determined that CET is effective in inhibiting dengue virus 1-4 (DENV1-4). Taken together, our findings indicate that CET could be an effective lead compound in the treatment of ZIKV and also suggest that further investigation and development of CET-derived drugs may lead to a new class of anti-Flavivirus medications. Twit Text FOAVip Cephalotaxine inhibits Zika infection by impeding viral replication and stability ????Biochem Biophys Res Commun http://www.kidney.de/pget.php?&tw=1&pmid=31818462 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=31818462 #FOAvip English Wikipedia <ref>{{Cite pmid|31818462}}</ref> Cephalotaxine inhibits Zika infection by impeding viral replication and stability #MMPMID31818462 Lai ZZ; Ho YJ; Lu JW Biochem Biophys Res Commun 2020[Feb]; 522 (4): 1052-1058 PMID31818462show ga The Zika virus (ZIKV) is a mosquito-borne flavivirus that has reemerged as a serious public health problem around the world. Syndromes of infected people range from asymptomatic infections to severe neurological disorders, such as Guillain-Barre syndrome and microcephaly. Screening anti-ZIKV drugs derived from Chinese medicinal herbs is one method of identifying antiviral agents. In this paper, we report that (1) Cephalotaxine (CET), an alkaloid isolated from Cephalotaxus drupacea, was effective in inhibiting ZIKV activity in vitro (i.e., in Vero and A549 cell lines) and (2) the mechanisms which underlie these effects involve virucidal activity and a decrease in viral replication. Specifically, CET was found to decrease ZIKV RNA and viral protein expression, inhibit ZIKV replication, and inhibit ZIKV mRNA/protein production. We also determined that CET is effective in inhibiting dengue virus 1-4 (DENV1-4). Taken together, our findings indicate that CET could be an effective lead compound in the treatment of ZIKV and also suggest that further investigation and development of CET-derived drugs may lead to a new class of anti-Flavivirus medications. |A549 Cells[MESH] |Animals[MESH] |Chlorocebus aethiops[MESH] |Dengue Virus/drug effects[MESH] |Homoharringtonine/*pharmacology[MESH] |Humans[MESH] |RNA Stability/drug effects[MESH] |RNA, Viral/biosynthesis[MESH] |Serotyping[MESH] |Vero Cells[MESH] |Virus Replication/*drug effects[MESH]Cephalotaxine inhibits Zika infection by impeding viral replication an(epmc).pdf DeepDyve Pubget Overpricing