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10.1002/tox.22882 http://scihub22266oqcxt.onion/10.1002/tox.22882 31794124!ä!31794124 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Environ+Toxicol 2020 ; 35 (4): 468-477 Nephropedia Template TP {{tp|p=31794124|t=2020. Deep sea minerals ameliorate diabetic-induced inflammation via inhibition of TNFalpha signaling pathways |pdf=|usr=}}{{31794124}} gab.com Text Deep sea minerals ameliorate diabetic-induced inflammation via inhibition of TNFalpha signaling pathways JO: Environ Toxicol http://www.kidney.de/pget.php?&tw=1&pmid=31794124 #FOAvip It has been well-documented that the consumption of deep sea water (DSW) has beneficial effects on myocardial hypertrophy and cardiac apoptosis induced by hypercholesterolemia. However, the molecular mechanisms for the anti-inflammatory effects of DSW on diabetic cardiomyopathy are still largely unclear. The main purpose of this present study was to test the hypothesis that DSW exerts anti-inflammatory effects through the suppression of the TNF-alpha-mediated signaling pathways. IP injection of streptozotocin (STZ) at the dose of 65 mg/kg was used to establish a diabetes rat model. DSW mineral extracts that diluted in desalinated water were prepared in three different dosages and administered to the rats through gavages for 4 weeks. These dosages are DSW-1X (equivalent to 37 mg Mg(2+) /kg/day), 2X (equivalent to 74 mg Mg(2+) /kg/day) and 3X (equivalent to 111 mg Mg(2+) mg/kg/day). Immunofluorescence staining and Western blot showed that the protein expression level of TNF-alpha was markedly higher in the STZ-induced diabetic rat hearts than in the control group. Consequently, the phosphorylation levels of the TNF-alpha-modulated downstream signaling molecules and P38 mitogen-activated protein kinases (MAPKs) were notably elevated in heart tissues of STZ-induced diabetes. These higher phosphorylation levels subsequently upregulated NF-kappaB-modulated inflammatory mediators, such as cyclooxygenase (COX)-II and inducible nitric oxide synthase (iNOS). However, treatment with DSW as well as MgSO(4) , the main mineral in DSW, significantly reversed all the alterations. These findings suggest that DSW has potential as a therapeutic agent for preventing diabetes-related cardiovascular diseases. Twit Text FOAVip Deep sea minerals ameliorate diabetic-induced inflammation via inhibition of TNFalpha signaling pathways ????Environ Toxicol http://www.kidney.de/pget.php?&tw=1&pmid=31794124 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=31794124 #FOAvip English Wikipedia <ref>{{Cite pmid|31794124}}</ref> Deep sea minerals ameliorate diabetic-induced inflammation via inhibition of TNFalpha signaling pathways #MMPMID31794124 Lu CH; Ou HC; Day CH; Chen HI; Pai PY; Lee CY; Chen RJ; Chang RL; PadmaViswanadha V; Hsieh DJ; Huang CY Environ Toxicol 2020[Apr]; 35 (4): 468-477 PMID31794124show ga It has been well-documented that the consumption of deep sea water (DSW) has beneficial effects on myocardial hypertrophy and cardiac apoptosis induced by hypercholesterolemia. However, the molecular mechanisms for the anti-inflammatory effects of DSW on diabetic cardiomyopathy are still largely unclear. The main purpose of this present study was to test the hypothesis that DSW exerts anti-inflammatory effects through the suppression of the TNF-alpha-mediated signaling pathways. IP injection of streptozotocin (STZ) at the dose of 65 mg/kg was used to establish a diabetes rat model. DSW mineral extracts that diluted in desalinated water were prepared in three different dosages and administered to the rats through gavages for 4 weeks. These dosages are DSW-1X (equivalent to 37 mg Mg(2+) /kg/day), 2X (equivalent to 74 mg Mg(2+) /kg/day) and 3X (equivalent to 111 mg Mg(2+) mg/kg/day). Immunofluorescence staining and Western blot showed that the protein expression level of TNF-alpha was markedly higher in the STZ-induced diabetic rat hearts than in the control group. Consequently, the phosphorylation levels of the TNF-alpha-modulated downstream signaling molecules and P38 mitogen-activated protein kinases (MAPKs) were notably elevated in heart tissues of STZ-induced diabetes. These higher phosphorylation levels subsequently upregulated NF-kappaB-modulated inflammatory mediators, such as cyclooxygenase (COX)-II and inducible nitric oxide synthase (iNOS). However, treatment with DSW as well as MgSO(4) , the main mineral in DSW, significantly reversed all the alterations. These findings suggest that DSW has potential as a therapeutic agent for preventing diabetes-related cardiovascular diseases. |Animals[MESH] |Anti-Inflammatory Agents/administration & dosage/*therapeutic use[MESH] |Diabetes Mellitus, Experimental/*drug therapy/immunology[MESH] |Diabetic Cardiomyopathies/immunology/*prevention & control[MESH] |Inflammation[MESH] |Male[MESH] |Minerals/administration & dosage/*therapeutic use[MESH] |Myocardium/immunology[MESH] |Myocytes, Cardiac/drug effects/immunology/pathology[MESH] |Rats[MESH] |Rats, Sprague-Dawley[MESH] |Seawater/*chemistry[MESH] |Signal Transduction[MESH] |Streptozocin[MESH]Deep sea minerals ameliorate diabetic-induced inflammation via inhibit(epmc).pdf DeepDyve Pubget Overpricing