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10.1016/j.bbrc.2019.11.112 http://scihub22266oqcxt.onion/10.1016/j.bbrc.2019.11.112 31791585!7218691!31791585     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Biochem+Biophys+Res+Commun 2020 ; 522 (3): 731-735 Nephropedia Template TP {{tp|p=31791585|t=2020. Protein phosphatase magnesium-dependent 1A induces inflammation in rheumatoid arthritis |pdf=|usr=}}{{31791585}} gab.com Text Protein phosphatase magnesium-dependent 1A induces inflammation in rheumatoid arthritis JO: Biochem Biophys Res Commun http://www.kidney.de/pget.php?&tw=1&pmid=31791585 #FOAvip Rheumatoid arthritis (RA) is a highly inflammatory autoimmune disease. Although proinflammatory cytokines, including tumor necrosis factor (TNF) and interleukin (IL)-6, play a key role in the pathogenesis of RA, the causes of chronic inflammation are not fully understood. Here, we report that protein phosphatase magnesium-dependent 1A (PPM1A) levels were increased in RA synovial fluid compared with osteoarthritis (OA) synovial fluid and positively correlated with TNF levels. In addition, PPM1A expression was increased in synovial tissue from RA patients and joint tissue from a mouse model of arthritis. Finally, extracellular PPM1A induced inflammation by stimulating macrophages to produce TNF through toll-like receptor 4 (TLR4) and myeloid differentiation primary response protein 88 (MyD88) signaling pathway. Our findings suggest that extracellular PPM1A may contribute to the pathogenesis of RA by functioning as a damage-associated molecular pattern (DAMP) to induce inflammation. Twit Text FOAVip Protein phosphatase magnesium-dependent 1A induces inflammation in rheumatoid arthritis ????Biochem Biophys Res Commun http://www.kidney.de/pget.php?&tw=1&pmid=31791585 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=31791585 #FOAvip English Wikipedia <ref>{{Cite pmid|31791585}}</ref> Protein phosphatase magnesium-dependent 1A induces inflammation in rheumatoid arthritis #MMPMID31791585 Lee B; Song YS; Rhodes C; Goh TS; Roh JS; Jeong H; Park J; Lee HN; Lee SG; Kim S; Kim M; Lee SI; Sohn DH; Robinson WH Biochem Biophys Res Commun 2020[Feb]; 522 (3): 731-735 PMID31791585show ga Rheumatoid arthritis (RA) is a highly inflammatory autoimmune disease. Although proinflammatory cytokines, including tumor necrosis factor (TNF) and interleukin (IL)-6, play a key role in the pathogenesis of RA, the causes of chronic inflammation are not fully understood. Here, we report that protein phosphatase magnesium-dependent 1A (PPM1A) levels were increased in RA synovial fluid compared with osteoarthritis (OA) synovial fluid and positively correlated with TNF levels. In addition, PPM1A expression was increased in synovial tissue from RA patients and joint tissue from a mouse model of arthritis. Finally, extracellular PPM1A induced inflammation by stimulating macrophages to produce TNF through toll-like receptor 4 (TLR4) and myeloid differentiation primary response protein 88 (MyD88) signaling pathway. Our findings suggest that extracellular PPM1A may contribute to the pathogenesis of RA by functioning as a damage-associated molecular pattern (DAMP) to induce inflammation. |Aged[MESH] |Animals[MESH] |Arthritis, Rheumatoid/*pathology[MESH] |Cells, Cultured[MESH] |Female[MESH] |Humans[MESH] |Inflammation/*pathology[MESH] |Male[MESH] |Mice[MESH] |Mice, Inbred C57BL[MESH] |Protein Phosphatase 2C/*analysis[MESH] |RAW 264.7 Cells[MESH] |Synovial Fluid/chemistry[MESH]Protein phosphatase magnesium-dependent 1A induces inflammation in rhe(epmc).pdf DeepDyve Pubget Overpricing