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10.1016/j.virol.2019.11.007 http://scihub22266oqcxt.onion/10.1016/j.virol.2019.11.007 31756532!7112109!31756532     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Virology 2020 ; 540 (ä): 45-56 Nephropedia Template TP {{tp|p=31756532|t=2020. Nucleocapsid proteins from other swine enteric coronaviruses differentially modulate PEDV replication |pdf=|usr=}}{{31756532}} gab.com Text Nucleocapsid proteins from other swine enteric coronaviruses differentially modulate PEDV replication JO: Virology http://www.kidney.de/pget.php?&tw=1&pmid=31756532 #FOAvip Porcine epidemic diarrhea virus (PEDV), transmissible gastroenteritis virus (TGEV) and porcine deltacoronavirus (PDCoV) share tropism for swine intestinal epithelial cells. Whether mixing of viral components during co-infection alters pathogenic outcomes or viral replication is not known. In this study, we investigated how different coronavirus nucleocapsid (CoV N) proteins interact and affect PEDV replication. We found that PDCoV N and TGEV N can competitively interact with PEDV N. However, the presence of PDCoV or TGEV N led to very different outcomes on PEDV replication. While PDCoV N significantly suppresses PEDV replication, overexpression of TGEV N, like that of PEDV N, increases production of PEDV RNA and virions. Despite partial interchangeability in nucleocapsid oligomerization and viral RNA synthesis, endogenous PEDV N cannot be replaced in the production of infectious PEDV particles. Results from this study give insights into functional compatibilities and evolutionary relationship between CoV viral proteins during viral co-infection and co-evolution. Twit Text FOAVip Nucleocapsid proteins from other swine enteric coronaviruses differentially modulate PEDV replication ????Virology http://www.kidney.de/pget.php?&tw=1&pmid=31756532 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=31756532 #FOAvip English Wikipedia <ref>{{Cite pmid|31756532}}</ref> Nucleocapsid proteins from other swine enteric coronaviruses differentially modulate PEDV replication #MMPMID31756532 Sungsuwan S; Jongkaewwattana A; Jaru-Ampornpan P Virology 2020[Jan]; 540 (ä): 45-56 PMID31756532show ga Porcine epidemic diarrhea virus (PEDV), transmissible gastroenteritis virus (TGEV) and porcine deltacoronavirus (PDCoV) share tropism for swine intestinal epithelial cells. Whether mixing of viral components during co-infection alters pathogenic outcomes or viral replication is not known. In this study, we investigated how different coronavirus nucleocapsid (CoV N) proteins interact and affect PEDV replication. We found that PDCoV N and TGEV N can competitively interact with PEDV N. However, the presence of PDCoV or TGEV N led to very different outcomes on PEDV replication. While PDCoV N significantly suppresses PEDV replication, overexpression of TGEV N, like that of PEDV N, increases production of PEDV RNA and virions. Despite partial interchangeability in nucleocapsid oligomerization and viral RNA synthesis, endogenous PEDV N cannot be replaced in the production of infectious PEDV particles. Results from this study give insights into functional compatibilities and evolutionary relationship between CoV viral proteins during viral co-infection and co-evolution. |*Microbial Interactions[MESH] |Animals[MESH] |Chlorocebus aethiops[MESH] |Coinfection/virology[MESH] |Coronavirus Nucleocapsid Proteins[MESH] |Coronavirus/growth & development[MESH] |Epithelial Cells/virology[MESH] |HEK293 Cells[MESH] |Humans[MESH] |Nucleocapsid Proteins/*metabolism[MESH] |Porcine epidemic diarrhea virus/*growth & development[MESH] |Transmissible gastroenteritis virus/growth & development[MESH]Nucleocapsid proteins from other swine enteric coronaviruses different(epmc).pdf DeepDyve Pubget Overpricing