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10.3390/medicina55110747 http://scihub22266oqcxt.onion/10.3390/medicina55110747 31752240!6915685!31752240     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=31752240&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       Medicina+(Kaunas) 2019 ; 55 (11): ? Nephropedia Template TP {{tp|p=31752240|t=2019. Could the Combination of Two Non-Psychotropic Cannabinoids Counteract Neuroinflammation? Effectiveness of Cannabidiol Associated with Cannabigerol |pdf=|usr=}}{{31752240}} gab.com Text Could the Combination of Two Non-Psychotropic Cannabinoids Counteract Neuroinflammation Effectiveness of Cannabidiol Associated with Cannabigerol JO: Medicina (Kaunas) http://www.kidney.de/pget.php?&tw=1&pmid=31752240 #FOAvip Background and Objectives: Neuroinflammation is associated with many neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS). In this study, we investigate the anti-inflammatory, anti-oxidant, and anti-apoptotic properties of two non-psychoactive phytocannabinoids, cannabigerol (CBG) and cannabidiol (CBD). Materials and Methods: The motoneuron-like cell line NSC-34 differentiated by serum deprivation and with the additional treatment of all-trans retinoic acid (RA) is a valid model to investigate molecular events linked to neurodegeneration in ALS. Results: Pre-treatment with CBG (at 2.5 and 5 microM doses) alone and in combination with CBD (at 2.5 and 5 microM doses) was able to reduce neuroinflammation induced by a culture medium of LPS-stimulated macrophages. In particular, the pre-treatment with CBD at a 5 microM dose decreased TNF-alpha levels and increased IL10 and IL-37 expression. CBG-CBD association at a 5 microM dose also reduced NF-kB nuclear factor activation with low degradation of the inhibitor of kappaB alpha (IkBalpha). CBG and CBD co-administered at a 5 microM dose decreased iNOS expression and increased Nrf2 levels. Furthermore, the pre-treatment with the association of two non-psychoactive cannabinoids downregulated Bax protein expression and upregulated Bcl-2 expression. Our data show the anti-inflammatory, anti-oxidant, and anti-apoptotic effects PPARgamma-mediated. Conclusions: Our results provide preliminary support on the potential therapeutic application of a CBG-CBD combination for further preclinical studies. Twit Text FOAVip Could the Combination of Two Non-Psychotropic Cannabinoids Counteract Neuroinflammation Effectiveness of Cannabidiol Associated with Cannabigerol ????Medicina (Kaunas) http://www.kidney.de/pget.php?&tw=1&pmid=31752240 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=31752240 #FOAvip English Wikipedia <ref>{{Cite pmid|31752240}}</ref> Could the Combination of Two Non-Psychotropic Cannabinoids Counteract Neuroinflammation? Effectiveness of Cannabidiol Associated with Cannabigerol #MMPMID31752240 Mammana S; Cavalli E; Gugliandolo A; Silvestro S; Pollastro F; Bramanti P; Mazzon E Medicina (Kaunas) 2019[Nov]; 55 (11): ? PMID31752240show ga Background and Objectives: Neuroinflammation is associated with many neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS). In this study, we investigate the anti-inflammatory, anti-oxidant, and anti-apoptotic properties of two non-psychoactive phytocannabinoids, cannabigerol (CBG) and cannabidiol (CBD). Materials and Methods: The motoneuron-like cell line NSC-34 differentiated by serum deprivation and with the additional treatment of all-trans retinoic acid (RA) is a valid model to investigate molecular events linked to neurodegeneration in ALS. Results: Pre-treatment with CBG (at 2.5 and 5 microM doses) alone and in combination with CBD (at 2.5 and 5 microM doses) was able to reduce neuroinflammation induced by a culture medium of LPS-stimulated macrophages. In particular, the pre-treatment with CBD at a 5 microM dose decreased TNF-alpha levels and increased IL10 and IL-37 expression. CBG-CBD association at a 5 microM dose also reduced NF-kB nuclear factor activation with low degradation of the inhibitor of kappaB alpha (IkBalpha). CBG and CBD co-administered at a 5 microM dose decreased iNOS expression and increased Nrf2 levels. Furthermore, the pre-treatment with the association of two non-psychoactive cannabinoids downregulated Bax protein expression and upregulated Bcl-2 expression. Our data show the anti-inflammatory, anti-oxidant, and anti-apoptotic effects PPARgamma-mediated. Conclusions: Our results provide preliminary support on the potential therapeutic application of a CBG-CBD combination for further preclinical studies. |Cannabidiol/standards/therapeutic use[MESH] |Cannabinoids/*standards/therapeutic use[MESH] |Cell Culture Techniques/methods[MESH] |Drug Therapy, Combination/methods/*standards/statistics & numerical data[MESH] |Humans[MESH] |Inflammation/*prevention & control[MESH] |Neurons/*drug effects[MESH]Could the Combination of Two Non-Psychotropic Cannabinoids Counteract (epmc).pdf DeepDyve Pubget Overpricing