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10.3390/v11111070 http://scihub22266oqcxt.onion/10.3390/v11111070 31744152!6893681!31744152     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Viruses 2019 ; 11 (11): ä Nephropedia Template TP {{tp|p=31744152|t=2019. A Multi-Omics Study of Chicken Infected by Nephropathogenic Infectious Bronchitis Virus |pdf=|usr=}}{{31744152}} gab.com Text A Multi-Omics Study of Chicken Infected by Nephropathogenic Infectious Bronchitis Virus JO: Viruses http://www.kidney.de/pget.php?&tw=1&pmid=31744152 #FOAvip Chicken gout resulting from nephropathogenic infectious bronchitis virus (NIBV) has become a serious kidney disease problem in chicken worldwide with alterations of the metabolic phenotypes in multiple metabolic pathways. To investigate the mechanisms in chicken responding to NIBV infection, we examined the global transcriptomic and metabolomic profiles of the chicken's kidney using RNA-seq and GC-TOF/MS, respectively. Furthermore, we analyzed the alterations in cecal microorganism composition in chickens using 16S rRNA-seq. Integrated analysis of these three phenotypic datasets further managed to create correlations between the altered kidney transcriptomes and metabolome, and between kidney metabolome and gut microbiome. We found that 2868 genes and 160 metabolites were deferentially expressed or accumulated in the kidney during NIBV infection processes. These genes and metabolites were linked to NIBV-infection related processes, including immune response, signal transduction, peroxisome, purine, and amino acid metabolism. In addition, the comprehensive correlations between the kidney metabolome and cecal microbial community showed contributions of gut microbiota in the progression of NIBV-infection. Taken together, our research comprehensively describes the host responses during NIBV infection and provides new clues for further dissection of specific gene functions, metabolite affections, and the role of gut microbiota during chicken gout. Twit Text FOAVip A Multi-Omics Study of Chicken Infected by Nephropathogenic Infectious Bronchitis Virus ????Viruses http://www.kidney.de/pget.php?&tw=1&pmid=31744152 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=31744152 #FOAvip English Wikipedia <ref>{{Cite pmid|31744152}}</ref> A Multi-Omics Study of Chicken Infected by Nephropathogenic Infectious Bronchitis Virus #MMPMID31744152 Xu P; Liu P; Zhou C; Shi Y; Wu Q; Yang Y; Li G; Hu G; Guo X Viruses 2019[Nov]; 11 (11): ä PMID31744152show ga Chicken gout resulting from nephropathogenic infectious bronchitis virus (NIBV) has become a serious kidney disease problem in chicken worldwide with alterations of the metabolic phenotypes in multiple metabolic pathways. To investigate the mechanisms in chicken responding to NIBV infection, we examined the global transcriptomic and metabolomic profiles of the chicken's kidney using RNA-seq and GC-TOF/MS, respectively. Furthermore, we analyzed the alterations in cecal microorganism composition in chickens using 16S rRNA-seq. Integrated analysis of these three phenotypic datasets further managed to create correlations between the altered kidney transcriptomes and metabolome, and between kidney metabolome and gut microbiome. We found that 2868 genes and 160 metabolites were deferentially expressed or accumulated in the kidney during NIBV infection processes. These genes and metabolites were linked to NIBV-infection related processes, including immune response, signal transduction, peroxisome, purine, and amino acid metabolism. In addition, the comprehensive correlations between the kidney metabolome and cecal microbial community showed contributions of gut microbiota in the progression of NIBV-infection. Taken together, our research comprehensively describes the host responses during NIBV infection and provides new clues for further dissection of specific gene functions, metabolite affections, and the role of gut microbiota during chicken gout. |*Genomics/methods[MESH] |*Host-Pathogen Interactions[MESH] |*Metabolomics/methods[MESH] |Animals[MESH] |Biopsy[MESH] |Chickens/*virology[MESH] |Computational Biology/methods[MESH] |Coronavirus Infections/*veterinary[MESH] |Dysbiosis[MESH] |Gas Chromatography-Mass Spectrometry[MESH] |Gastrointestinal Microbiome[MESH] |Gene Expression Profiling[MESH] |Immunohistochemistry[MESH] |Infectious bronchitis virus/*physiology[MESH] |Organ Specificity[MESH] |Poultry Diseases/*diagnosis/genetics/metabolism/*virology[MESH] |Symptom Assessment[MESH]A Multi-Omics Study of Chicken Infected by Nephropathogenic Infectious(epmc).pdf DeepDyve Pubget Overpricing