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10.1038/s41598-019-52278-3 http://scihub22266oqcxt.onion/10.1038/s41598-019-52278-3 31676833!6825220!31676833     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Rep 2019 ; 9 (1): 15857 Nephropedia Template TP {{tp|p=31676833|t=2019. The HIV protease inhibitor darunavir prevents kidney injury via HIV-independent mechanisms |pdf=|usr=}}{{31676833}} gab.com Text The HIV protease inhibitor darunavir prevents kidney injury via HIV-independent mechanisms JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=31676833 #FOAvip HIV-associated nephropathy (HIVAN) is a rapidly progressive kidney disease that is caused by HIV infection of renal epithelial cells with subsequent expression of viral genes, including vpr. Antiretroviral therapy ameliorates HIVAN without eradicating HIV from the kidneys and the mechanism by which it protects kidneys is poorly understood. Since HIV protease inhibitors have "off target" cellular effects, we studied whether darunavir, the most commonly prescribed protease inhibitor, protects kidneys from HIV-induced injury via mechanisms independent of HIV protease and viral replication. Renal epithelial cells were transduced with lentiviruses encoding HIV (lacking protease and reverse transcriptase), Vpr, or vector control. Darunavir attenuated HIV and Vpr-induced activation of Stat3, Src, Erk, and cytokines, which are critical for HIVAN pathogenesis. We then studied HIV-transgenic mice, which develop HIVAN in the absence of HIV protease or reverse transcriptase. Mice were treated with darunavir, zidovudine, darunavir + zidovudine, or control. Darunavir and darunavir + zidovudine reduced albuminuria and histologic kidney injury and normalized expression of dysregulated proteins. RNA-seq analyses demonstrated that darunavir suppressed HIV-induced upregulation of immune response genes in human kidney cells. These data demonstrate that darunavir protects against HIV-induced renal injury via mechanisms that are independent of inhibition of HIV protease. Twit Text FOAVip The HIV protease inhibitor darunavir prevents kidney injury via HIV-independent mechanisms ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=31676833 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=31676833 #FOAvip English Wikipedia <ref>{{Cite pmid|31676833}}</ref> The HIV protease inhibitor darunavir prevents kidney injury via HIV-independent mechanisms #MMPMID31676833 Gao X; Rosales A; Karttunen H; Bommana GM; Tandoh B; Yi Z; Habib Z; D'Agati V; Zhang W; Ross MJ Sci Rep 2019[Nov]; 9 (1): 15857 PMID31676833show ga HIV-associated nephropathy (HIVAN) is a rapidly progressive kidney disease that is caused by HIV infection of renal epithelial cells with subsequent expression of viral genes, including vpr. Antiretroviral therapy ameliorates HIVAN without eradicating HIV from the kidneys and the mechanism by which it protects kidneys is poorly understood. Since HIV protease inhibitors have "off target" cellular effects, we studied whether darunavir, the most commonly prescribed protease inhibitor, protects kidneys from HIV-induced injury via mechanisms independent of HIV protease and viral replication. Renal epithelial cells were transduced with lentiviruses encoding HIV (lacking protease and reverse transcriptase), Vpr, or vector control. Darunavir attenuated HIV and Vpr-induced activation of Stat3, Src, Erk, and cytokines, which are critical for HIVAN pathogenesis. We then studied HIV-transgenic mice, which develop HIVAN in the absence of HIV protease or reverse transcriptase. Mice were treated with darunavir, zidovudine, darunavir + zidovudine, or control. Darunavir and darunavir + zidovudine reduced albuminuria and histologic kidney injury and normalized expression of dysregulated proteins. RNA-seq analyses demonstrated that darunavir suppressed HIV-induced upregulation of immune response genes in human kidney cells. These data demonstrate that darunavir protects against HIV-induced renal injury via mechanisms that are independent of inhibition of HIV protease. |AIDS-Associated Nephropathy/metabolism/pathology/*prevention & control[MESH] |Animals[MESH] |Cell Line[MESH] |Darunavir/*pharmacology[MESH] |HIV Protease Inhibitors/*pharmacology[MESH] |HIV-1/*metabolism[MESH] |Humans[MESH] |Kidney/*metabolism/pathology/virology[MESH] |MAP Kinase Signaling System/*drug effects[MESH] |Mice[MESH] |Mice, Transgenic[MESH]The HIV protease inhibitor darunavir prevents kidney injury via HIV-in(epmc).pdf DeepDyve Pubget Overpricing