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10.4103/CJP.CJP_48_19 http://scihub22266oqcxt.onion/10.4103/CJP.CJP_48_19 31670284!ä!31670284 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Chin+J+Physiol 2019 ; 62 (5): 203-209 Nephropedia Template TP {{tp|p=31670284|t=2019. Magnesium sulfate attenuates lipopolysaccharides-induced acute lung injury in mice |pdf=|usr=}}{{31670284}} gab.com Text Magnesium sulfate attenuates lipopolysaccharides-induced acute lung injury in mice JO: Chin J Physiol http://www.kidney.de/pget.php?&tw=1&pmid=31670284 #FOAvip Acute lung injury (ALI) is a common and severe respiratory disease with high morbidity and mortality. Although some progress has been made in the past years, the pathogenesis of ALI is still poorly understood and the therapeutic outcome has still not been significantly improved. It is well-recognized that magnesium sulfate (MgSO(4)) possesses potent anti-inflammation capacity. The present study was designed to investigate the protective effects of MgSO(4) in lipopolysaccharides (LPSs)-induced ALI taken into account that excessive inflammatory response plays critical role in the development of ALI. In this study, Kunming mice were intravenously injected with LPS through tail vein to establish the ALI model and in parallel, A549 cells were used to establish cell model. The lung wet-to-dry weight ratio, malondialdehyde (MDA) levels in lung tissue, lung permeability index, hematoxylin and eosin staining, cytokines in the serum and bronchoalveolar lavage fluid (BALF), neutrophil counts in BALF, LPS-induced A549 cell apoptosis as well as apoptosis-inducing factor (AIF), and Poly(ADP-ribose) polymerase-1 (PARP-1) expression in both mice and A549 cells were detected. Our results demonstrated that MgSO(4) significantly attenuated the LPS-induced ALI, oxidative stress (decreased MDA levels), and lung inflammatory response. Moreover, MgSO(4) exerted protective effects by mitigating LPS-induced A549 cell apoptosis. Furthermore, MgSO(4) decreased the AIF and PARP-1 expression both in vivo and in vitro. Our results, taken together, demonstrated that MgSO(4) is a potential therapeutic agent for ALI taken into consideration that MgSO(4) is commonly used in clinical settings. Twit Text FOAVip Magnesium sulfate attenuates lipopolysaccharides-induced acute lung injury in mice ????Chin J Physiol http://www.kidney.de/pget.php?&tw=1&pmid=31670284 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=31670284 #FOAvip English Wikipedia <ref>{{Cite pmid|31670284}}</ref> Magnesium sulfate attenuates lipopolysaccharides-induced acute lung injury in mice #MMPMID31670284 Li W; Wu X; Yu J; Ma C; Zhuang P; Zeng J; Zhang J; Deng G; Wang Y Chin J Physiol 2019[Sep]; 62 (5): 203-209 PMID31670284show ga Acute lung injury (ALI) is a common and severe respiratory disease with high morbidity and mortality. Although some progress has been made in the past years, the pathogenesis of ALI is still poorly understood and the therapeutic outcome has still not been significantly improved. It is well-recognized that magnesium sulfate (MgSO(4)) possesses potent anti-inflammation capacity. The present study was designed to investigate the protective effects of MgSO(4) in lipopolysaccharides (LPSs)-induced ALI taken into account that excessive inflammatory response plays critical role in the development of ALI. In this study, Kunming mice were intravenously injected with LPS through tail vein to establish the ALI model and in parallel, A549 cells were used to establish cell model. The lung wet-to-dry weight ratio, malondialdehyde (MDA) levels in lung tissue, lung permeability index, hematoxylin and eosin staining, cytokines in the serum and bronchoalveolar lavage fluid (BALF), neutrophil counts in BALF, LPS-induced A549 cell apoptosis as well as apoptosis-inducing factor (AIF), and Poly(ADP-ribose) polymerase-1 (PARP-1) expression in both mice and A549 cells were detected. Our results demonstrated that MgSO(4) significantly attenuated the LPS-induced ALI, oxidative stress (decreased MDA levels), and lung inflammatory response. Moreover, MgSO(4) exerted protective effects by mitigating LPS-induced A549 cell apoptosis. Furthermore, MgSO(4) decreased the AIF and PARP-1 expression both in vivo and in vitro. Our results, taken together, demonstrated that MgSO(4) is a potential therapeutic agent for ALI taken into consideration that MgSO(4) is commonly used in clinical settings. |*Acute Lung Injury[MESH] |Animals[MESH] |Bronchoalveolar Lavage Fluid[MESH] |Inflammation[MESH] |Lipopolysaccharides[MESH] |Lung[MESH] |Magnesium Sulfate[MESH]Magnesium sulfate attenuates lipopolysaccharides-induced acute lung in(epmc).pdf DeepDyve Pubget Overpricing