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10.1016/j.virol.2019.10.011 http://scihub22266oqcxt.onion/10.1016/j.virol.2019.10.011 31670218!7112098!31670218     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Virology 2020 ; 539 (ä): 38-48 Nephropedia Template TP {{tp|p=31670218|t=2020. Porcine deltacoronavirus (PDCoV) modulates calcium influx to favor viral replication |pdf=|usr=}}{{31670218}} gab.com Text Porcine deltacoronavirus (PDCoV) modulates calcium influx to favor viral replication JO: Virology http://www.kidney.de/pget.php?&tw=1&pmid=31670218 #FOAvip Ionic calcium (Ca(2+)) is a versatile intracellular second messenger that plays important roles in cellular physiological and pathological processes. Porcine deltacoronavirus (PDCoV) is an emerging enteropathogenic coronavirus that causes serious vomiting and diarrhea in suckling piglets. In this study, the role of Ca(2+) to PDCoV infection was investigated. PDCoV infection was found to upregulate intracellular Ca(2+) concentrations of IPI-2I cells. Chelating extracellular Ca(2+) by EGTA inhibited PDCoV replication, and this inhibitory effect was overcome by replenishment with CaCl(2). Treatment with Ca(2+) channel blockers, particularly the L-type Ca(2+) channel blocker diltiazem hydrochloride, inhibited PDCoV infection significantly. Mechanistically, diltiazem hydrochloride reduces PDCoV infection by inhibiting the replication step of the viral replication cycle. Additionally, knockdown of CACNA1S, the L-type Ca(2+) voltage-gated channel subunit, inhibited PDCoV replication. The combined results demonstrate that PDCoV modulates calcium influx to favor its replication. Twit Text FOAVip Porcine deltacoronavirus (PDCoV) modulates calcium influx to favor viral replication ????Virology http://www.kidney.de/pget.php?&tw=1&pmid=31670218 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=31670218 #FOAvip English Wikipedia <ref>{{Cite pmid|31670218}}</ref> Porcine deltacoronavirus (PDCoV) modulates calcium influx to favor viral replication #MMPMID31670218 Bai D; Fang L; Xia S; Ke W; Wang J; Wu X; Fang P; Xiao S Virology 2020[Jan]; 539 (ä): 38-48 PMID31670218show ga Ionic calcium (Ca(2+)) is a versatile intracellular second messenger that plays important roles in cellular physiological and pathological processes. Porcine deltacoronavirus (PDCoV) is an emerging enteropathogenic coronavirus that causes serious vomiting and diarrhea in suckling piglets. In this study, the role of Ca(2+) to PDCoV infection was investigated. PDCoV infection was found to upregulate intracellular Ca(2+) concentrations of IPI-2I cells. Chelating extracellular Ca(2+) by EGTA inhibited PDCoV replication, and this inhibitory effect was overcome by replenishment with CaCl(2). Treatment with Ca(2+) channel blockers, particularly the L-type Ca(2+) channel blocker diltiazem hydrochloride, inhibited PDCoV infection significantly. Mechanistically, diltiazem hydrochloride reduces PDCoV infection by inhibiting the replication step of the viral replication cycle. Additionally, knockdown of CACNA1S, the L-type Ca(2+) voltage-gated channel subunit, inhibited PDCoV replication. The combined results demonstrate that PDCoV modulates calcium influx to favor its replication. |*Virus Replication[MESH] |Animals[MESH] |Calcium Signaling[MESH] |Calcium/*metabolism[MESH] |Coronavirus Infections/*metabolism/*virology[MESH] |Coronavirus/*physiology[MESH] |Swine[MESH] |Swine Diseases/*metabolism/*virology[MESH]Porcine deltacoronavirus (PDCoV) modulates calcium influx to favor vir(epmc).pdf DeepDyve Pubget Overpricing