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10.1021/acsami.9b15032 http://scihub22266oqcxt.onion/10.1021/acsami.9b15032 31633330!7075527!31633330     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       ACS+Appl+Mater+Interfaces 2019 ; 11 (46): 42964-42974 Nephropedia Template TP {{tp|p=31633330|t=2019. Functional Carbon Quantum Dots as Medical Countermeasures to Human Coronavirus |pdf=|usr=}}{{31633330}} gab.com Text Functional Carbon Quantum Dots as Medical Countermeasures to Human Coronavirus JO: ACS Appl Mater Interfaces http://www.kidney.de/pget.php?&tw=1&pmid=31633330 #FOAvip Therapeutic options for the highly pathogenic human coronavirus (HCoV) infections are urgently needed. Anticoronavirus therapy is however challenging, as coronaviruses are biologically diverse and rapidly mutating. In this work, the antiviral activity of seven different carbon quantum dots (CQDs) for the treatment of human coronavirus HCoV-229E infections was investigated. The first generation of antiviral CQDs was derived from hydrothermal carbonization of ethylenediamine/citric acid as carbon precursors and postmodified with boronic acid ligands. These nanostructures showed a concentration-dependent virus inactivation with an estimated EC(50) of 52 +/- 8 mug mL(-1). CQDs derived from 4-aminophenylboronic acid without any further modification resulted in the second-generation of anti-HCoV nanomaterials with an EC(50) lowered to 5.2 +/- 0.7 mug mL(-1). The underlying mechanism of action of these CQDs was revealed to be inhibition of HCoV-229E entry that could be due to interaction of the functional groups of the CQDs with HCoV-229E entry receptors; surprisingly, an equally large inhibition activity was observed at the viral replication step. Twit Text FOAVip Functional Carbon Quantum Dots as Medical Countermeasures to Human Coronavirus ????ACS Appl Mater Interfaces http://www.kidney.de/pget.php?&tw=1&pmid=31633330 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=31633330 #FOAvip English Wikipedia <ref>{{Cite pmid|31633330}}</ref> Functional Carbon Quantum Dots as Medical Countermeasures to Human Coronavirus #MMPMID31633330 Loczechin A; Seron K; Barras A; Giovanelli E; Belouzard S; Chen YT; Metzler-Nolte N; Boukherroub R; Dubuisson J; Szunerits S ACS Appl Mater Interfaces 2019[Nov]; 11 (46): 42964-42974 PMID31633330show ga Therapeutic options for the highly pathogenic human coronavirus (HCoV) infections are urgently needed. Anticoronavirus therapy is however challenging, as coronaviruses are biologically diverse and rapidly mutating. In this work, the antiviral activity of seven different carbon quantum dots (CQDs) for the treatment of human coronavirus HCoV-229E infections was investigated. The first generation of antiviral CQDs was derived from hydrothermal carbonization of ethylenediamine/citric acid as carbon precursors and postmodified with boronic acid ligands. These nanostructures showed a concentration-dependent virus inactivation with an estimated EC(50) of 52 +/- 8 mug mL(-1). CQDs derived from 4-aminophenylboronic acid without any further modification resulted in the second-generation of anti-HCoV nanomaterials with an EC(50) lowered to 5.2 +/- 0.7 mug mL(-1). The underlying mechanism of action of these CQDs was revealed to be inhibition of HCoV-229E entry that could be due to interaction of the functional groups of the CQDs with HCoV-229E entry receptors; surprisingly, an equally large inhibition activity was observed at the viral replication step. |*Antiviral Agents/pharmacology[MESH] |*Carbon/chemistry/pharmacology[MESH] |*Coronavirus Infections/drug therapy/metabolism/pathology[MESH] |*Quantum Dots/chemistry/therapeutic use[MESH] |Cell Line, Tumor[MESH] |Coronavirus 229E, Human/*physiology[MESH] |Humans[MESH]Functional Carbon Quantum Dots as Medical Countermeasures to Human Cor(epmc).pdf DeepDyve Pubget Overpricing