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10.1177/0271678X19877403 http://scihub22266oqcxt.onion/10.1177/0271678X19877403 31558107!7430096!31558107     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Cereb+Blood+Flow+Metab 2020 ; 40 (9): 1869-1878 Nephropedia Template TP {{tp|p=31558107|t=2020. Cortical microinfarcts in memory clinic patients are associated with reduced cerebral perfusion |pdf=|usr=}}{{31558107}} gab.com Text Cortical microinfarcts in memory clinic patients are associated with reduced cerebral perfusion JO: J Cereb Blood Flow Metab http://www.kidney.de/pget.php?&tw=1&pmid=31558107 #FOAvip Cerebral cortical microinfarcts (CMIs) are small ischemic lesions associated with cognitive impairment and dementia. CMIs are frequently observed in cortical watershed areas suggesting that hypoperfusion contributes to their development. We investigated if presence of CMIs was related to a decrease in cerebral perfusion, globally or specifically in cortex surrounding CMIs. In 181 memory clinic patients (mean age 72 +/- 9 years, 51% male), CMI presence was rated on 3-T magnetic resonance imaging (MRI). Cerebral perfusion was assessed from cortical gray matter of the anterior circulation using pseudo-continuous arterial spin labeling parameters cerebral blood flow (CBF) (perfusion in mL blood/100 g tissue/min) and spatial coefficient of variation (CoV) (reflecting arterial transit time (ATT)). Patients with CMIs had a 12% lower CBF (beta = -.20) and 22% higher spatial CoV (beta = .20) (both p < .05) without a specific regional pattern on voxel-based CBF analysis. CBF in a 2 cm region-of-interest around the CMIs did not differ from CBF in a reference zone in the contralateral hemisphere. These findings show that CMIs in memory clinic patients are primarily related to global reductions in cerebral perfusion, thus shedding new light on the etiology of vascular brain injury in dementia. Twit Text FOAVip Cortical microinfarcts in memory clinic patients are associated with reduced cerebral perfusion ????J Cereb Blood Flow Metab http://www.kidney.de/pget.php?&tw=1&pmid=31558107 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=31558107 #FOAvip English Wikipedia <ref>{{Cite pmid|31558107}}</ref> Cortical microinfarcts in memory clinic patients are associated with reduced cerebral perfusion #MMPMID31558107 Ferro DA; Mutsaerts HJ; Hilal S; Kuijf HJ; Petersen ET; Petr J; van Veluw SJ; Venketasubramanian N; Yeow TB; Biessels GJ; Chen C J Cereb Blood Flow Metab 2020[Sep]; 40 (9): 1869-1878 PMID31558107show ga Cerebral cortical microinfarcts (CMIs) are small ischemic lesions associated with cognitive impairment and dementia. CMIs are frequently observed in cortical watershed areas suggesting that hypoperfusion contributes to their development. We investigated if presence of CMIs was related to a decrease in cerebral perfusion, globally or specifically in cortex surrounding CMIs. In 181 memory clinic patients (mean age 72 +/- 9 years, 51% male), CMI presence was rated on 3-T magnetic resonance imaging (MRI). Cerebral perfusion was assessed from cortical gray matter of the anterior circulation using pseudo-continuous arterial spin labeling parameters cerebral blood flow (CBF) (perfusion in mL blood/100 g tissue/min) and spatial coefficient of variation (CoV) (reflecting arterial transit time (ATT)). Patients with CMIs had a 12% lower CBF (beta = -.20) and 22% higher spatial CoV (beta = .20) (both p < .05) without a specific regional pattern on voxel-based CBF analysis. CBF in a 2 cm region-of-interest around the CMIs did not differ from CBF in a reference zone in the contralateral hemisphere. These findings show that CMIs in memory clinic patients are primarily related to global reductions in cerebral perfusion, thus shedding new light on the etiology of vascular brain injury in dementia. |Aged[MESH] |Aged, 80 and over[MESH] |Brain Infarction/*complications/diagnostic imaging[MESH] |Cerebral Cortex/diagnostic imaging/pathology/*physiopathology[MESH] |Cerebrovascular Circulation/*physiology[MESH] |Cognitive Dysfunction/etiology[MESH] |Dementia/etiology[MESH] |Female[MESH] |Humans[MESH] |Magnetic Resonance Imaging[MESH] |Male[MESH] |Memory Disorders[MESH]Cortical microinfarcts in memory clinic patients are associated with r(epmc).pdf DeepDyve Pubget Overpricing