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10.1111/tid.13180 http://scihub22266oqcxt.onion/10.1111/tid.13180 31544324!6917841!31544324     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Transpl+Infect+Dis 2019 ; 21 (6): e13180 Nephropedia Template TP {{tp|p=31544324|t=2019. Butyrate-producing gut bacteria and viral infections in kidney transplant recipients: A pilot study |pdf=|usr=}}{{31544324}} gab.com Text Butyrate-producing gut bacteria and viral infections in kidney transplant recipients: A pilot study JO: Transpl Infect Dis http://www.kidney.de/pget.php?&tw=1&pmid=31544324 #FOAvip BACKGROUND: The gut microbiome is being associated increasingly with development of infections besides Clostridium difficile infection. A recent study found an association between butyrate-producing gut (BPG) bacteria and less frequent development of lower respiratory viral infections in allogeneic hematopoietic stem cell transplant recipients (Haak et al, Blood 131(26): 2978, 2018). In this investigation, we examine the relationship between the abundance of BPG bacteria and the development of viral infections in a cohort of kidney transplant recipients. METHODS: We recruited 168 kidney transplant recipients who provided 510 fecal specimens in the first 3 months after transplantation and profiled the gut microbiota using 16S rRNA gene sequencing of the V4-V5 hypervariable region. We classified the kidney transplant recipients into higher BPG Bacteria Group and lower BPG Bacteria Group using the same criteria of 1% relative gut abundance of BPG bacteria as the Haak et al study. RESULTS: Administration of antibiotics against anaerobes was associated with a significant decrease in the relative gut abundance of BPG bacteria. The higher BPG Bacteria Group was associated with less development of respiratory viral infections (Hazard Ratio [HR]: 0.28, P = .01) but not with less development of CMV viremia (HR: 0.38, P = .13) or BK viremia (HR: 1.02, P = .98) at 2 years post transplantation. CONCLUSION: Our pilot investigation supports future validation of the relationship between high relative gut abundance of BPG bacteria and decreased risk for development of respiratory viral infections. Twit Text FOAVip Butyrate-producing gut bacteria and viral infections in kidney transplant recipients: A pilot study ????Transpl Infect Dis http://www.kidney.de/pget.php?&tw=1&pmid=31544324 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=31544324 #FOAvip English Wikipedia <ref>{{Cite pmid|31544324}}</ref> Butyrate-producing gut bacteria and viral infections in kidney transplant recipients: A pilot study #MMPMID31544324 Lee JR; Huang J; Magruder M; Zhang LT; Gong C; Sholi AN; Albakry S; Edusei E; Muthukumar T; Lubetzky M; Dadhania DM; Taur Y; Pamer EG; Suthanthiran M Transpl Infect Dis 2019[Dec]; 21 (6): e13180 PMID31544324show ga BACKGROUND: The gut microbiome is being associated increasingly with development of infections besides Clostridium difficile infection. A recent study found an association between butyrate-producing gut (BPG) bacteria and less frequent development of lower respiratory viral infections in allogeneic hematopoietic stem cell transplant recipients (Haak et al, Blood 131(26): 2978, 2018). In this investigation, we examine the relationship between the abundance of BPG bacteria and the development of viral infections in a cohort of kidney transplant recipients. METHODS: We recruited 168 kidney transplant recipients who provided 510 fecal specimens in the first 3 months after transplantation and profiled the gut microbiota using 16S rRNA gene sequencing of the V4-V5 hypervariable region. We classified the kidney transplant recipients into higher BPG Bacteria Group and lower BPG Bacteria Group using the same criteria of 1% relative gut abundance of BPG bacteria as the Haak et al study. RESULTS: Administration of antibiotics against anaerobes was associated with a significant decrease in the relative gut abundance of BPG bacteria. The higher BPG Bacteria Group was associated with less development of respiratory viral infections (Hazard Ratio [HR]: 0.28, P = .01) but not with less development of CMV viremia (HR: 0.38, P = .13) or BK viremia (HR: 1.02, P = .98) at 2 years post transplantation. CONCLUSION: Our pilot investigation supports future validation of the relationship between high relative gut abundance of BPG bacteria and decreased risk for development of respiratory viral infections. |Anti-Bacterial Agents/adverse effects[MESH] |Antibiotic Prophylaxis/adverse effects[MESH] |Bacteria/drug effects/immunology/*isolation & purification/metabolism[MESH] |Bacterial Infections/immunology/prevention & control[MESH] |Butyrates/metabolism[MESH] |DNA, Bacterial/isolation & purification[MESH] |Feces/microbiology[MESH] |Female[MESH] |Follow-Up Studies[MESH] |Gastrointestinal Microbiome/drug effects/*physiology[MESH] |Graft Rejection/immunology/prevention & control[MESH] |Humans[MESH] |Immunosuppressive Agents/adverse effects[MESH] |Kidney Transplantation/*adverse effects[MESH] |Male[MESH] |Middle Aged[MESH] |Pilot Projects[MESH] |RNA, Ribosomal, 16S/genetics[MESH] |Respiratory Tract Infections/*epidemiology/immunology/virology[MESH]Butyrate-producing gut bacteria and viral infections in kidney transpl(epmc).pdf DeepDyve Pubget Overpricing