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10.1016/j.bbrc.2019.07.091 http://scihub22266oqcxt.onion/10.1016/j.bbrc.2019.07.091 31526569!ä!31526569 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Biochem+Biophys+Res+Commun 2019 ; 519 (3): 445-452 Nephropedia Template TP {{tp|p=31526569|t=2019. Activation of Dusp14 protects against osteoclast generation and bone loss by regulating AMPKalpha-dependent manner |pdf=|usr=}}{{31526569}} gab.com Text Activation of Dusp14 protects against osteoclast generation and bone loss by regulating AMPKalpha-dependent manner JO: Biochem Biophys Res Commun http://www.kidney.de/pget.php?&tw=1&pmid=31526569 #FOAvip Osteoporosis is a progressive systematic skeletal disorder featured by decreased bone and enhanced risk of fracture due to an uncoupling of bone resorption. Chronic inflammatory response plays an essential role in osteoporosis progression. Unfortunately, the pathogenesis that contributes to osteoporosis still remains unclear. Dual-specificity phosphatase 14 (Dusp14, also known as MKP6) is a MAP kinase phosphatase, and has important roles in regulating various cellular processes. In the study, we attempted to explore the effects of Dusp14 on osteoporosis development. The results indicated that Dusp14 expression was decreased during osteoclast differentiation and that Dusp14 over-expression markedly alleviated osteoclast generation regulated by macrophage colony-stimulating factor (M-CSF) and receptor activator of NF-kappaB ligand (RANKL). In M-CSF/RANKL-treated bone marrow-derived cells (BMMs), promoting Dusp14 expression significantly alleviated inflammation and apoptosis by suppressing nuclear factor (NF)-kappaB and Caspase-3 signaling pathways, respectively. Furthermore, AMP-activated protein kinase (AMPK)-alpha activation was markedly increased by Dusp14 over-expression in M-CSF/RANKL-incubated BMMs. Importantly, we found that AMPKalpha blockage obviously abolished the role of Dusp14 in preventing osteoclasts differentiation at least partly via elevating M-CSF/RANKL-elicited inflammation and apoptosis. In vivo, magnesium silicate-induced inflammatory osteoporosis was obviously alleviated in Dusp14 transgenic (TG) mice. Taken together, we defined Dusp14 as an important molecular switch resulting in osteoporosis through an AMPKalpha-dependent manner. Twit Text FOAVip Activation of Dusp14 protects against osteoclast generation and bone loss by regulating AMPKalpha-dependent manner ????Biochem Biophys Res Commun http://www.kidney.de/pget.php?&tw=1&pmid=31526569 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=31526569 #FOAvip English Wikipedia <ref>{{Cite pmid|31526569}}</ref> Activation of Dusp14 protects against osteoclast generation and bone loss by regulating AMPKalpha-dependent manner #MMPMID31526569 Hong L; Ai J; Ma D Biochem Biophys Res Commun 2019[Nov]; 519 (3): 445-452 PMID31526569show ga Osteoporosis is a progressive systematic skeletal disorder featured by decreased bone and enhanced risk of fracture due to an uncoupling of bone resorption. Chronic inflammatory response plays an essential role in osteoporosis progression. Unfortunately, the pathogenesis that contributes to osteoporosis still remains unclear. Dual-specificity phosphatase 14 (Dusp14, also known as MKP6) is a MAP kinase phosphatase, and has important roles in regulating various cellular processes. In the study, we attempted to explore the effects of Dusp14 on osteoporosis development. The results indicated that Dusp14 expression was decreased during osteoclast differentiation and that Dusp14 over-expression markedly alleviated osteoclast generation regulated by macrophage colony-stimulating factor (M-CSF) and receptor activator of NF-kappaB ligand (RANKL). In M-CSF/RANKL-treated bone marrow-derived cells (BMMs), promoting Dusp14 expression significantly alleviated inflammation and apoptosis by suppressing nuclear factor (NF)-kappaB and Caspase-3 signaling pathways, respectively. Furthermore, AMP-activated protein kinase (AMPK)-alpha activation was markedly increased by Dusp14 over-expression in M-CSF/RANKL-incubated BMMs. Importantly, we found that AMPKalpha blockage obviously abolished the role of Dusp14 in preventing osteoclasts differentiation at least partly via elevating M-CSF/RANKL-elicited inflammation and apoptosis. In vivo, magnesium silicate-induced inflammatory osteoporosis was obviously alleviated in Dusp14 transgenic (TG) mice. Taken together, we defined Dusp14 as an important molecular switch resulting in osteoporosis through an AMPKalpha-dependent manner. |AMP-Activated Protein Kinases/*metabolism[MESH] |Animals[MESH] |Bone Marrow Cells/drug effects/metabolism[MESH] |Bone Resorption/genetics/*metabolism[MESH] |Cells, Cultured[MESH] |Dual-Specificity Phosphatases/genetics/*metabolism[MESH] |Enzyme Activation[MESH] |Gene Expression/drug effects[MESH] |Macrophage Colony-Stimulating Factor/pharmacology[MESH] |Macrophages/drug effects/metabolism[MESH] |Male[MESH] |Mice, Inbred C57BL[MESH] |Mice, Transgenic[MESH] |Mitogen-Activated Protein Kinase Phosphatases/genetics/*metabolism[MESH] |Osteoclasts/*metabolism[MESH]Activation of Dusp14 protects against osteoclast generation and bone l(epmc).pdf DeepDyve Pubget Overpricing