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10.1165/rcmb.2019-0050OC http://scihub22266oqcxt.onion/10.1165/rcmb.2019-0050OC 31513749!ä!31513749 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Am+J+Respir+Cell+Mol+Biol 2020 ; 62 (3): 331-341 Nephropedia Template TP {{tp|p=31513749|t=2020. PI3K Catalytic Subunits alpha and beta Modulate Cell Death and IL-6 Secretion Induced by Talc Particles in Human Lung Carcinoma Cells |pdf=|usr=}}{{31513749}} gab.com Text PI3K Catalytic Subunits alpha and beta Modulate Cell Death and IL-6 Secretion Induced by Talc Particles in Human Lung Carcinoma Cells JO: Am J Respir Cell Mol Biol http://www.kidney.de/pget.php?&tw=1&pmid=31513749 #FOAvip Hydrated magnesium silicate (or "talc" particles) is a sclerosis agent commonly used in the management of malignant pleural effusions, a common symptom of metastatic diseases, including lung cancers. However, the direct effects of talc particles to lung carcinoma cells, which can be found in the malignant pleural effusion fluids from patients with lung cancer, are not fully understood. Here, we report a study of the signaling pathways that can modulate the cell death and IL-6 secretion induced by talc particles in human lung carcinoma cells. We found that talc-sensitive cells have higher mRNA and protein expression of PI3K catalytic subunits alpha and beta. Further experiments confirmed that modulation (inhibition or activation) of the PI3K pathway reduces or enhances cellular sensitivity to talc particles, respectively, independent of the inflammasome. By knocking down specific PI3K isoforms, we also confirmed that both PI3Kalpha and -beta mediate the observed talc effects. Our results suggest a novel role of the PI3K pathway in talc-induced cell death and IL-6 secretion in lung carcinoma cells. These cellular events are known to drive fibrosis, and thus further studies of the PI3K pathway may provide a better understanding of the mechanisms of talc sclerosis in the malignant pleural space. Twit Text FOAVip PI3K Catalytic Subunits alpha and beta Modulate Cell Death and IL-6 Secretion Induced by Talc Particles in Human Lung Carcinoma Cells ????Am J Respir Cell Mol Biol http://www.kidney.de/pget.php?&tw=1&pmid=31513749 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=31513749 #FOAvip English Wikipedia <ref>{{Cite pmid|31513749}}</ref> PI3K Catalytic Subunits alpha and beta Modulate Cell Death and IL-6 Secretion Induced by Talc Particles in Human Lung Carcinoma Cells #MMPMID31513749 Bougen-Zhukov NM; Lee YY; Lee JJ; Lee P; Loo LH Am J Respir Cell Mol Biol 2020[Mar]; 62 (3): 331-341 PMID31513749show ga Hydrated magnesium silicate (or "talc" particles) is a sclerosis agent commonly used in the management of malignant pleural effusions, a common symptom of metastatic diseases, including lung cancers. However, the direct effects of talc particles to lung carcinoma cells, which can be found in the malignant pleural effusion fluids from patients with lung cancer, are not fully understood. Here, we report a study of the signaling pathways that can modulate the cell death and IL-6 secretion induced by talc particles in human lung carcinoma cells. We found that talc-sensitive cells have higher mRNA and protein expression of PI3K catalytic subunits alpha and beta. Further experiments confirmed that modulation (inhibition or activation) of the PI3K pathway reduces or enhances cellular sensitivity to talc particles, respectively, independent of the inflammasome. By knocking down specific PI3K isoforms, we also confirmed that both PI3Kalpha and -beta mediate the observed talc effects. Our results suggest a novel role of the PI3K pathway in talc-induced cell death and IL-6 secretion in lung carcinoma cells. These cellular events are known to drive fibrosis, and thus further studies of the PI3K pathway may provide a better understanding of the mechanisms of talc sclerosis in the malignant pleural space. |Actins/physiology[MESH] |Adenocarcinoma/*enzymology/metabolism/pathology[MESH] |Carcinoma, Non-Small-Cell Lung/*enzymology/metabolism/pathology[MESH] |Cell Death[MESH] |Cell Line, Tumor[MESH] |Class II Phosphatidylinositol 3-Kinases/biosynthesis/genetics/*physiology[MESH] |Drug Resistance[MESH] |Enzyme Induction[MESH] |Humans[MESH] |Interleukin-6/metabolism[MESH] |Lung Neoplasms/*enzymology/metabolism/pathology[MESH] |Neoplasm Proteins/antagonists & inhibitors/*physiology[MESH] |Pleural Effusion, Malignant/chemistry[MESH] |Protein Kinase Inhibitors/pharmacology[MESH] |Protein Subunits[MESH] |RNA Interference[MESH] |RNA, Messenger/biosynthesis/genetics[MESH] |RNA, Neoplasm/biosynthesis/genetics[MESH] |RNA, Small Interfering/genetics[MESH] |Sclerosing Solutions/*pharmacology[MESH] |Signal Transduction[MESH] |Talc/*pharmacology[MESH]PI3K Catalytic Subunits alpha and beta Modulate Cell Death and IL-6 Se(epmc).pdf DeepDyve Pubget Overpricing