Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1021/acscentsci.9b00509 http://scihub22266oqcxt.onion/10.1021/acscentsci.9b00509 31482128!6716342!31482128     free     free     free       ACS+Cent+Sci 2019 ; 5 (8): 1449-1460 Nephropedia Template TP {{tp|p=31482128|t=2019. Chemical Fingerprint of Zn-Hydroxyapatite in the Early Stages of Osteogenic Differentiation |pdf=|usr=}}{{31482128}} gab.com Text Chemical Fingerprint of Zn-Hydroxyapatite in the Early Stages of Osteogenic Differentiation JO: ACS Cent Sci http://www.kidney.de/pget.php?&tw=1&pmid=31482128 #FOAvip The core knowledge about biomineralization is provided by studies on the advanced phases of the process mainly occurring in the extracellular matrix. Here, we investigate the early stages of biomineralization by evaluating the chemical fingerprint of the initial mineral nuclei deposition in the intracellular milieu and their evolution toward hexagonal hydroxyapatite. The study is conducted on human bone mesenchymal stem cells exposed to an osteogenic cocktail for 4 and 10 days, exploiting laboratory X-ray diffraction techniques and cutting-edge developments of synchrotron-based 2D and 3D cryo-X-ray microscopy. We demonstrate that biomineralization starts with Zn-hydroxyapatite nucleation within the cell, rapidly evolving toward hexagonal hydroxyapatite crystals, very similar in composition and structure to the one present in human bone. These results provide experimental evidence of the germinal role of Zn in hydroxyapatite nucleation and foster further studies on the intracellular molecular mechanisms governing the initial phases of bone tissue formation. Twit Text FOAVip Chemical Fingerprint of Zn-Hydroxyapatite in the Early Stages of Osteogenic Differentiation ????ACS Cent Sci http://www.kidney.de/pget.php?&tw=1&pmid=31482128 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=31482128 #FOAvip English Wikipedia <ref>{{Cite pmid|31482128}}</ref> Chemical Fingerprint of Zn-Hydroxyapatite in the Early Stages of Osteogenic Differentiation #MMPMID31482128 Procopio A; Malucelli E; Pacureanu A; Cappadone C; Farruggia G; Sargenti A; Castiglioni S; Altamura D; Sorrentino A; Giannini C; Pereiro E; Cloetens P; Maier JAM; Iotti S ACS Cent Sci 2019[Aug]; 5 (8): 1449-1460 PMID31482128show ga The core knowledge about biomineralization is provided by studies on the advanced phases of the process mainly occurring in the extracellular matrix. Here, we investigate the early stages of biomineralization by evaluating the chemical fingerprint of the initial mineral nuclei deposition in the intracellular milieu and their evolution toward hexagonal hydroxyapatite. The study is conducted on human bone mesenchymal stem cells exposed to an osteogenic cocktail for 4 and 10 days, exploiting laboratory X-ray diffraction techniques and cutting-edge developments of synchrotron-based 2D and 3D cryo-X-ray microscopy. We demonstrate that biomineralization starts with Zn-hydroxyapatite nucleation within the cell, rapidly evolving toward hexagonal hydroxyapatite crystals, very similar in composition and structure to the one present in human bone. These results provide experimental evidence of the germinal role of Zn in hydroxyapatite nucleation and foster further studies on the intracellular molecular mechanisms governing the initial phases of bone tissue formation. ?Chemical Fingerprint of Zn-Hydroxyapatite in the Early Stages of Osteo(epmc).pdf DeepDyve Pubget Overpricing