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10.3389/fnmol.2019.00194 http://scihub22266oqcxt.onion/10.3389/fnmol.2019.00194 31481873!6710442!31481873     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Front+Mol+Neurosci 2019 ; 12 (ä): 194 Nephropedia Template TP {{tp|p=31481873|t=2019. Hydrogen Sulfide Inhibits High Glucose-Induced Neuronal Senescence by Improving Autophagic Flux via Up-regulation of SIRT1 |pdf=|usr=}}{{31481873}} gab.com Text Hydrogen Sulfide Inhibits High Glucose-Induced Neuronal Senescence by Improving Autophagic Flux via Up-regulation of SIRT1 JO: Front Mol Neurosci http://www.kidney.de/pget.php?&tw=1&pmid=31481873 #FOAvip Hyperglycemia, a key characteristic and risk factor for diabetes mellitus (DM), causes neuronal senescence. Hydrogen sulfide (H(2)S) is a novel neuroprotectant. The present work was to investigate the potential effect of H(2)S on hyperglycemia-induced neuronal senescence and the underlying mechanisms. We found that NaHS, a donor of H(2)S, inhibited high glucose (HG)-induced cellular senescence in HT22 cells (an immortalized mouse hippocampal cell line), as evidenced by a decrease in the number of senescence associated-beta-galactosidase (SA-beta-gal) positive cells, increase in the growth of cells, and down-regulations of senescence mark proteins, p16(INK4a) and p21(CIP1). NaHS improved the autophagic flux, which is judged by a decrease in the amount of intracellular autophagosome as well as up-regulations of LC3II/I and P62 in HG-exposed HT22 cells. Furthermore, blocked autophagic flux by chloroquine (CQ) significantly abolished NaHS-exerted improvement in the autophagic flux and suppression in the cellular senescence of GH-exposed HT22 cells, which indicated that H(2)S antagonizes HG-induced neuronal senescence by promoting autophagic flux. We also found that NaHS up-regulated the expression of silent mating type information regulation 2 homolog 1 (SIRT1), an important anti-aging protein, in HG-exposed HT22 cells. Furthermore, inhibition of SIRT1 by sirtinol reversed the protection of H(2)S against HG-induced autophagic flux blockade and cellular senescence in HT22 cells. These data indicated that H(2)S protects HT22 cells against HG-induced neuronal senescence by improving autophagic flux via up-regulation of SIRT1, suggesting H(2)S as a potential treatment strategy for hyperglycemia-induced neuronal senescence and neurotoxicity. Twit Text FOAVip Hydrogen Sulfide Inhibits High Glucose-Induced Neuronal Senescence by Improving Autophagic Flux via Up-regulation of SIRT1 ????Front Mol Neurosci http://www.kidney.de/pget.php?&tw=1&pmid=31481873 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=31481873 #FOAvip English Wikipedia <ref>{{Cite pmid|31481873}}</ref> Hydrogen Sulfide Inhibits High Glucose-Induced Neuronal Senescence by Improving Autophagic Flux via Up-regulation of SIRT1 #MMPMID31481873 Wu L; Chen Y; Wang CY; Tang YY; Huang HL; Kang X; Li X; Xie YR; Tang XQ Front Mol Neurosci 2019[]; 12 (ä): 194 PMID31481873show ga Hyperglycemia, a key characteristic and risk factor for diabetes mellitus (DM), causes neuronal senescence. Hydrogen sulfide (H(2)S) is a novel neuroprotectant. The present work was to investigate the potential effect of H(2)S on hyperglycemia-induced neuronal senescence and the underlying mechanisms. We found that NaHS, a donor of H(2)S, inhibited high glucose (HG)-induced cellular senescence in HT22 cells (an immortalized mouse hippocampal cell line), as evidenced by a decrease in the number of senescence associated-beta-galactosidase (SA-beta-gal) positive cells, increase in the growth of cells, and down-regulations of senescence mark proteins, p16(INK4a) and p21(CIP1). NaHS improved the autophagic flux, which is judged by a decrease in the amount of intracellular autophagosome as well as up-regulations of LC3II/I and P62 in HG-exposed HT22 cells. Furthermore, blocked autophagic flux by chloroquine (CQ) significantly abolished NaHS-exerted improvement in the autophagic flux and suppression in the cellular senescence of GH-exposed HT22 cells, which indicated that H(2)S antagonizes HG-induced neuronal senescence by promoting autophagic flux. We also found that NaHS up-regulated the expression of silent mating type information regulation 2 homolog 1 (SIRT1), an important anti-aging protein, in HG-exposed HT22 cells. Furthermore, inhibition of SIRT1 by sirtinol reversed the protection of H(2)S against HG-induced autophagic flux blockade and cellular senescence in HT22 cells. These data indicated that H(2)S protects HT22 cells against HG-induced neuronal senescence by improving autophagic flux via up-regulation of SIRT1, suggesting H(2)S as a potential treatment strategy for hyperglycemia-induced neuronal senescence and neurotoxicity. äHydrogen Sulfide Inhibits High Glucose-Induced Neuronal Senescence by (epmc).pdf DeepDyve Pubget Overpricing