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10.1016/j.blre.2019.100610 http://scihub22266oqcxt.onion/10.1016/j.blre.2019.100610 31471128!7014586!31471128     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Blood+Rev 2020 ; 39 (ä): 100610 Nephropedia Template TP {{tp|p=31471128|t=2020. The role of beta-2-glycoprotein I in health and disease associating structure with function: More than just APS |pdf=|usr=}}{{31471128}} gab.com Text The role of beta-2-glycoprotein I in health and disease associating structure with function: More than just APS JO: Blood Rev http://www.kidney.de/pget.php?&tw=1&pmid=31471128 #FOAvip Beta-2-Glycoprotein I (beta2GPI) plays a number of essential roles throughout the body. beta2GPI, C-reactive protein and thrombomodulin are the only three proteins that possess the dual capability to up and down regulate the complement and coagulation systems depending upon external stimulus. Clinically, beta2GPI is the primary antigen in the autoimmune condition antiphospholipid syndrome (APS), which is typically characterised by pregnancy morbidity and vascular thrombosis. This protein is also capable of adopting at least two distinct structural forms, but it has been argued that several other intermediate forms may exist. Thus, beta2GPI is a unique protein with a key role in haemostasis, homeostasis and immunity. In this review, we examine the genetics, structure and function of beta2GPI in the body and how these factors may influence its contribution to disease pathogenesis. We also consider the clinical implications of beta2GPI in the diagnosis of APS and as a potentially novel therapeutic target. Twit Text FOAVip The role of beta-2-glycoprotein I in health and disease associating structure with function: More than just APS ????Blood Rev http://www.kidney.de/pget.php?&tw=1&pmid=31471128 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=31471128 #FOAvip English Wikipedia <ref>{{Cite pmid|31471128}}</ref> The role of beta-2-glycoprotein I in health and disease associating structure with function: More than just APS #MMPMID31471128 McDonnell T; Wincup C; Buchholz I; Pericleous C; Giles I; Ripoll V; Cohen H; Delcea M; Rahman A Blood Rev 2020[Jan]; 39 (ä): 100610 PMID31471128show ga Beta-2-Glycoprotein I (beta2GPI) plays a number of essential roles throughout the body. beta2GPI, C-reactive protein and thrombomodulin are the only three proteins that possess the dual capability to up and down regulate the complement and coagulation systems depending upon external stimulus. Clinically, beta2GPI is the primary antigen in the autoimmune condition antiphospholipid syndrome (APS), which is typically characterised by pregnancy morbidity and vascular thrombosis. This protein is also capable of adopting at least two distinct structural forms, but it has been argued that several other intermediate forms may exist. Thus, beta2GPI is a unique protein with a key role in haemostasis, homeostasis and immunity. In this review, we examine the genetics, structure and function of beta2GPI in the body and how these factors may influence its contribution to disease pathogenesis. We also consider the clinical implications of beta2GPI in the diagnosis of APS and as a potentially novel therapeutic target. |Animals[MESH] |Antiphospholipid Syndrome/*blood[MESH] |Humans[MESH]The role of beta-2-glycoprotein I in health and disease associating st(epmc).pdf DeepDyve Pubget Overpricing